Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0519 Transporter Info | ||||
| Gene Name | CACNA1B | ||||
| Protein Name | Voltage-gated calcium channel alpha Cav2.2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs2229949 | ||||
| Site of GPD | chr9:138122079 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>T | ||||
| Minor Allele Frequency | C=0.1375/510 (Global) | ||||
| Genotype CC | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Antipsychotics | N.A. | Major Depressive Disorder | Genotype CC is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype TT. | [ 1] | |
| Antipsychotics | N.A. | Schizophrenia | Correlated with the increased drug response in patients (compare with genotype TT) | [ 1] | |
| Genetic Polymorphism | rs2739260 | ||||
| Site of GPD | chr9:138117612 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>G | ||||
| Minor Allele Frequency | A=0.6440/1274 (Global) | ||||
| Genotypes AG + GG | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Nicardipine | N.A. | Major Depressive Disorder | Genotypes AG + GG is associated with increased clinical benefit to nicardipine or nimodipine in people with Bipolar Disorder as compared to genotype AA. | [ 2] | |
| Nimodipine | N.A. | Major Depressive Disorder | Genotypes AG + GG is associated with increased clinical benefit to nicardipine or nimodipine in people with Bipolar Disorder as compared to genotype AA. | [ 2] | |
| Genetic Polymorphism | rs2739258 | ||||
| Site of GPD | chr9:138116189 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>G | ||||
| Minor Allele Frequency | A=0.6470/1280 (Global) | ||||
| Genotypes AG + GG | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Nicardipine | N.A. | Major Depressive Disorder | Genotypes AG + GG is associated with increased clinical benefit to nicardipine or nimodipine in people with Bipolar Disorder as compared to genotype AA. | [ 2] | |
| Nimodipine | N.A. | Major Depressive Disorder | Genotypes AG + GG is associated with increased clinical benefit to nicardipine or nimodipine in people with Bipolar Disorder as compared to genotype AA. | [ 2] | |
| References | |||||
| 1 | Variation within voltage-gated calcium channel genes and antipsychotic treatment response in a South African first episode schizophrenia cohort. Pharmacogenomics J. 2019 Feb;19(1):109-114. | ||||
| 2 | A pilot pharmacogenetic study of calcium channel blocker treatment of bipolar mania. Psychiatry Res. 2023 Aug;326:115281. | ||||
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