Drug Transporter (DT) Information

General Information of DT
DT ID DTD0383
Gene Name SLC4A2
Protein Name Anion exchange protein 2
Gene ID
6522
UniProt ID
P04920
TCDB ID
2.A.31.1.2
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4YZF_A

Identity:58.207%

Minimized Score:-1903.285 kcal/mol

Detail: Structure Info

Synonyms AE 2; AE2; Anion exchanger 2; BND3L; EPB3L1; HKB3; MPB3L; NBND3; Non-erythroid band 3-like protein; SLC4A2; Solute carrier family 4 member 2
DT Family Anion Exchanger (AE) Family ;
Function This transporter is a plasma membrane anion exchange protein of wide distribution.
Endogenous Substrate(s) Cl-
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Anion exchange protein 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Anion exchange protein 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Anion exchange protein 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Anion exchange protein 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Anion exchange protein 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Anion exchange protein 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Anion exchange protein 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Anion exchange protein 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Anion exchange protein 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Bicarbonate
 Phase 3 Drug Info Metabolic acidosis 5C73 [1]
References
1 HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16934-9.

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