Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0383 Transporter Info
Gene Name SLC4A2
Transporter Name Anion exchange protein 2
Gene ID
6522
UniProt ID
P04920
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in decreased expression of SLC4A2 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

  abrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 abrine results in increased expression of SLC4A2 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in increased expression of SLC4A2 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  Arsenic Trioxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arsenic Trioxide results in increased stability of and results in increased expression of SLC4A2 protein [15]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene results in increased methylation of SLC4A2 3' UTR [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene results in increased methylation of SLC4A2 5' UTR [16]

Regulation Mechanism

 Transcription Factor Info

  Bicarbonates

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC4A2 protein affects the transport of Chlorides co-treated with Bicarbonates [17]

Regulation Mechanism

 Transcription Factor Info

  boric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 boric acid results in increased expression of SLC4A2 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  Chlorides

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC4A2 protein affects the transport of Chlorides co-treated with Bicarbonates [17]

Regulation Mechanism

 Transcription Factor Info

  Dexamethasone

          14 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dexamethasone promotes the reaction EP300 protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Dexamethasone promotes the reaction HNF1A protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 glycoursodeoxycholic acid co-treated with Dexamethasone results in increased expression of SLC4A2 mRNA alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 taurine-ursodeoxycholate conjugate co-treated with Dexamethasone results in increased expression of SLC4A2 mRNA alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction EP300 protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction EP300 protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation8

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation9

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction HNF1A protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation10

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction HNF1A protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation11

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation12

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction NR3C1 protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation13

 Ursodeoxycholic Acid co-treated with Dexamethasone results in increased activity of SLC4A2 protein [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation14

 Ursodeoxycholic Acid co-treated with Dexamethasone results in increased expression of SLC4A2 mRNA alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  Diazinon

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Diazinon results in increased methylation of SLC4A2 gene [21]

Regulation Mechanism

 Transcription Factor Info

  Dichlorodiphenyl Dichloroethylene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dichlorodiphenyl Dichloroethylene results in decreased expression of SLC4A2 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

  di-n-butylphosphoric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 di-n-butylphosphoric acid affects the expression of SLC4A2 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  glycoursodeoxycholic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 glycoursodeoxycholic acid co-treated with Dexamethasone results in increased expression of SLC4A2 mRNA alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  ICG 001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG 001 results in decreased expression of SLC4A2 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

  Ozone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Air Pollutants results in increased abundance of Ozone which affects the expression of SLC4A2 mRNA [24]

Regulation Mechanism

 Transcription Factor Info

  Silicon Dioxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Silicon Dioxide results in decreased expression of SLC4A2 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  Thiram

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Thiram results in increased expression of SLC4A2 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

  Ursodeoxycholic Acid

          12 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction EP300 protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction EP300 protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction HNF1A protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction HNF1A protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation8

 Ursodeoxycholic Acid co-treated with Dexamethasone promotes the reaction NR3C1 protein binds to SLC4A2 promoter alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation9

 Ursodeoxycholic Acid co-treated with Dexamethasone results in increased activity of SLC4A2 protein [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation10

 Ursodeoxycholic Acid co-treated with Dexamethasone results in increased expression of SLC4A2 mRNA alternative form [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation11

 Ursodeoxycholic Acid promotes the reaction EP300 protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation12

 Ursodeoxycholic Acid promotes the reaction HNF1A protein binds to SLC4A2 promoter [20]

Regulation Mechanism

 Transcription Factor Info

Carcinogen

  Arsenic

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arsenic affects the methylation of SLC4A2 gene [14]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Folic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Folic Acid inhibits the expression of SLC4A2 [1]

  Zidovudine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zidovudine increases the expression of SLC4A2 [2]

  Cisplatin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cisplatin increases the expression of SLC4A2 [3]

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the expression of SLC4A2 [4]

  Doxorubicin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Doxorubicin inhibits the expression of SLC4A2 [5]

  Temozolomide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Temozolomide inhibits the expression of SLC4A2 [6]

  Ivermectin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ivermectin inhibits the expression of SLC4A2 [7]

  Valproic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid increases the expression of SLC4A2 [8]

  Rifampicin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Rifampicin induces the activity of SLC4A2 [9]

Patented Pharmaceutical Agent

  ICG-001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG-001 inhibits the expression of SLC4A2 [10]

Natural Product

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution increases the expression of SLC4A2 [11]

  Caffeine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Caffeine affects the phosphorylation of SLC4A2 protein [19]

Regulation Mechanism

 Transcription Factor Info
References
1 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92.
2 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
3 Low Doses of Cisplatin Induce Gene Alterations, Cell Cycle Arrest, and Apoptosis in Human Promyelocytic Leukemia Cells. Biomark Insights. 2016 Aug 24;11:113-21.
4 Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
5 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
6 Temozolomide induces activation of Wnt/beta-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278.
7 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975.
8 Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
9 Rifampicin Induces Bicarbonate-Rich Choleresis in Rats: Involvement of Anion Exchanger 2. Dig Dis Sci. 2016 Jan;61(1):126-36.
10 Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
11 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
12 Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
13 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
14 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106.
15 Anion exchanger 2 mediates the action of arsenic trioxide. Br J Haematol. 2006;134(5):491-9.
16 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
17 Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells. FEBS Lett. 2002;512(1-3):52-8.
18 Boric acid increases the expression levels of human anion exchanger genes SLC4A2 and SLC4A3. Genet Mol Res. 2012;11(2):847-54.
19 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022;449:116110.
20 Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells. J Clin Invest. 2008;118(2):695-709.
21 Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro. Environ Toxicol Pharmacol. 2012;34(3):959-68.
22 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
23 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
24 Ozone exposure and blood transcriptome: A randomized, controlled, crossover trial among healthy adults. Environ Int. 2022;163:107242.
25 Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet. 2015;24(5):1374-89.

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