Drug Information

General Information
Drug ID
DR00142
Drug Name
L-alanine
Synonyms
(2S)-2-Aminopropanoic acid; (C14)L-Alanine; (L)-Alanine; (S)-(+)-Alanine; (S)-2-Aminopropanoic acid; (S)-2-Aminopropionic acid; (S)-2-Aminopropionsaeure; (S)-Alanine; (S)-alpha-Aminopropionsaeure; 14C-L-Alanine; 2-Aminopropionic acid; A-Alanine; A-Aminopropionic acid; ALA; Alanina; Alanina [DCIT,Spanish]; Alanine; Alanine (USP); Alanine (VAN); Alanine [USAN:INN]; Alanine, L-(7CI,8CI); Alaninum; Alaninum [Latin]; Alpha-Alanine; Alpha-Aminopropionic acid; F4F207FF-8FF8-4789-99A1-147AE0A36673; H-Ala-OH; L-&alpha-alanine; L-(+)-Alanine; L-2-Aminopropanoic acid; L-2-Aminopropionic acid; L-2-Aminopropionsaeure; L-A-Aminopropionicacid; L-Alanin; L-Alanine (9CI); L-Alanine (JAN); L-Alanine, N-coco alkyl derivs.;Propanoic acid, 2-amino-, (S); L-Alanine, homopolymer; L-Alanine, labeled with carbon-14; L-Alanine, labeled with tritium; L-S-Aminopropionic acid; L-a-Alanine; L-a-Aminopropionic acid; L-alpha-Aminopropionic acid; L-alpha-alanine; LPG; Poly-DL-alanine; Poly-L-alanine; Polyalanine
Drug Type
Small molecular drug
Indication Dietary shortage [ICD11:5B7Z] Approved [1]
Glioma [ICD11:2A00.0] Approved [1]
Therapeutic Class
Dietary supplement
Structure
3D MOL 2D MOL
Formula
C3H7NO2
Canonical SMILES
CC(C(=O)O)N
InChI
InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
InChIKey
QNAYBMKLOCPYGJ-REOHCLBHSA-N
CAS Number
CAS 56-41-7
Pharmaceutical Properties Molecular Weight 89.09 Topological Polar Surface Area 63.3
Heavy Atom Count 6 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
XLogP
-3
PubChem CID
5950
PubChem SID
103059020 ,103059733 ,103182286 ,103827139 ,103914796 ,104234104 ,104310701 ,10527484 ,11113404 ,11528607 ,14710664 ,14720011 ,14747373 ,24845820 ,24890849 ,24891241 ,24891260 ,24901893 ,29224973 ,3131856 ,3343 ,46504866 ,46508779 ,49655376 ,56437668 ,57323073 ,57580857 ,585842 ,589753 ,627087 ,6436532 ,78123937 ,7847080 ,7885836 ,7888688 ,8144737 ,8153694 ,822335 ,841591 ,85164877 ,85230829 ,85239779 ,87350317 ,87561861 ,92297527 ,92719579 ,96100165 ,96100173 ,99224270 ,99246016
ChEBI ID
ChEBI:16977
TTD Drug ID
D09PUL
DT(s) Transporting This Drug ASCT1 Transporter Info Alanine/serine/cysteine/threonine transporter 1 Substrate [2]
LAT2 Transporter Info L-type amino acid transporter 2 Substrate [3]
SNAT1 Transporter Info Sodium-coupled neutral amino acid transporter 1 Substrate [4]
SNAT2 Transporter Info Sodium-coupled neutral amino acid transporter 2 Substrate [4]
SNAT3 Transporter Info Sodium-coupled neutral amino acid transporter 3 Substrate [4]
SNAT4 Transporter Info Sodium-coupled neutral amino acid transporter 4 Substrate [4]
SNAT5 Transporter Info Sodium-coupled neutral amino acid transporter 5 Substrate [4]
Drug-Transporter Activity Data
Drug-Transporter Activity Data ASCT1 Transporter Info Km =194 microM Rat hippocampal astrocyte-ASCT1 [2]
References
1 L-alanine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.
3 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20)
4 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.

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