Drug Transporter (DT) Information

General Information of DT
DT ID DTD0331
Gene Name SLC38A4
Protein Name Sodium-coupled neutral amino acid transporter 4
Gene ID
55089
UniProt ID
Q969I6
TCDB ID
2.A.18.6.17
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms ATA3; Amino acid transporter A3; NAT3; Na(+)-coupled neutral amino acid transporter 4; PAAT; SLC38A4; SNAT4; Solute carrier family 38 member 4; System A amino acid transporter 3; System N amino acid transporter 3
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Detected in embryonic and adult liver, and atlower levels in adult muscle, kidney and pancreas. Detected inplacenta syncytiotrophoblasts throughout gestation. Detected infetal blood vessels.
Function This sodium-dependent transporter mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6. 5, intermediate at pH 7. 0 and highest between pH 7. 5 and 8. 5.
Disease(s) Short bowel syndrome [ICD-11:KB89.1]
Endogenous Substrate(s) Alanine; Histidine; Cysteine; Asparagine; Serine; Glycine; Valine; Threonine; Glutamine; Methionine
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-coupled neutral amino acid transporter 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-coupled neutral amino acid transporter 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-coupled neutral amino acid transporter 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium-coupled neutral amino acid transporter 4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-coupled neutral amino acid transporter 4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-coupled neutral amino acid transporter 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-coupled neutral amino acid transporter 4
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-coupled neutral amino acid transporter 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-coupled neutral amino acid transporter 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-alanine
 Approved Drug Info Glioma 2A00.0 [1]
L-glutamine
 Approved Drug Info Short bowel syndrome KB89.1 [1]
References
1 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.

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