Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0331 Transporter Info
Gene Name	SLC38A4
Transporter Name	Sodium-coupled neutral amino acid transporter 4
Gene ID	55089
UniProt ID	Q969I6

Post-Translational Modification of This DT
Overview ofSLC38A4 Modification Sites with Functional and Structural Information
Sequence	M D P M E L R N V N I E P D D E S S S G E S A P D S Y I G I G N S E K A A M S S Q F A N E D T E S Q K F L T N G F L G K K K L A D Y A D E H H P G T T S F G M S S F N L S N A I M G S G I L G L S Y A M A N T G I I L F I I M L L A V A I L S L Y S V H L L L K T A K E G G S L I Y E K L G E K A F G W P G K I G A F V S I T M Q N I G A M S S Y L F I I K Y E L P E V I R A F M G L E E N T G E W Y L N G N Y L I I F V S V G I I L P L S L L K N L G Y L G Y T S G F S L T C M V F F V S V V I Y K K F Q I P C P L P V L D H S V G N L S F N N T L P M H V V M L P N N S E S S D V N F M M D Y T H R N P A G L D E N Q A K G S L H D S G V E Y E A H S D D K C E P K Y F V F N S R T A Y A I P I L V F A F V C H P E V L P I Y S E L K D R S R R K M Q T V S N I S I T G M L V M Y L L A A L F G Y L T F Y G E V E D E L L H A Y S K V Y T L D I P L L M V R L A V L V A V T L T V P I V L F P I R T S V I T L L F P K R P F S W I R H F L I A A V L I A L N N V L V I L V P T I K Y I F G F I G A S S A T M L I F I L P A V F Y L K L V K K E T F R S P Q K V G A L I F L V V G I F F M I G S M A L I I I D W I Y D P P N S K H H
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC38A4			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	260
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC38A4 Asparagine 260 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC38A4			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	264
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC38A4 Asparagine 264 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC38A4			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	276
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC38A4 Asparagine 276 has the potential to affect its expression or activity.
Phosphorylation
Serine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC38A4			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	17
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Serine 17 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC38A4			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	18
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Serine 18 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC38A4			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	19
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Serine 19 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC38A4			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	22
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Serine 22 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC38A4			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	26
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Serine 26 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC38A4			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	33
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Serine 33 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC38A4			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	40
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Serine 40 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC38A4			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	49
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Serine 49 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC38A4			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	214
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Serine 214 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC38A4			[4], [8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	47
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Threonine 47 has the potential to affect its expression or activity.
Tyrosine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC38A4			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	27
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Tyrosine 27 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	313
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Tyrosine 313 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	313
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Tyrosine 313 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	313
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A4 Tyrosine 313 has the potential to affect its expression or activity.

References
1	Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. J Biol Chem. 2011 Nov 4;286(44):38086-38094.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S38A4_HUMAN)
3	In situ sample processing approach (iSPA) for comprehensive quantitative phosphoproteome analysis. J Proteome Res. 2014 Sep 5;13(9):3896-904.
4	Non-alcoholic fatty liver disease phosphoproteomics: A functional piece of the precision puzzle. Hepatol Res. 2017 Dec;47(13):1469-1483.
5	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62.
6	Systematic analysis of protein phosphorylation networks from phosphoproteomic data. Mol Cell Proteomics. 2012 Oct;11(10):1070-83.
7	An Impaired Respiratory Electron Chain Triggers Down-regulation of the Energy Metabolism and De-ubiquitination of Solute Carrier Amino Acid Transporters. Mol Cell Proteomics. 2016 May;15(5):1526-38.
8	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
9	Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity. Mol Cell Proteomics. 2018 May;17(5):836-849.
10	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
11	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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