Drug Transporter (DT) Information

General Information of DT
DT ID DTD0332
Gene Name SLC38A5
Protein Name Sodium-coupled neutral amino acid transporter 5
Gene ID
92745
UniProt ID
Q8WUX1
TCDB ID
2.A.18.6.15
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms JM24; SLC38A5; SN2; SNAT5; Solute carrier family 38 member 5; System N transporter 2; pp7194
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Predominantly expressed in stomach, brain,liver, lung and intestinal tract.
Function This transporter functions as a sodium-dependent amino acid transporter and mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.
Disease(s) Short bowel syndrome [ICD-11:KB89.1]
Endogenous Substrate(s) Glycine; Asparagine; Alanine; Serine; Glutamine; Histidine
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-coupled neutral amino acid transporter 5
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-coupled neutral amino acid transporter 5
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-coupled neutral amino acid transporter 5
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium-coupled neutral amino acid transporter 5
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-coupled neutral amino acid transporter 5
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-coupled neutral amino acid transporter 5
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-coupled neutral amino acid transporter 5
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-coupled neutral amino acid transporter 5
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-coupled neutral amino acid transporter 5
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-alanine
 Approved Drug Info Glioma 2A00.0 [1]
L-glutamine
 Approved Drug Info Short bowel syndrome KB89.1 [1]
References
1 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.

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