Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0332 Transporter Info
Gene Name SLC38A5
Transporter Name Sodium-coupled neutral amino acid transporter 5
Gene ID
92745
UniProt ID
Q8WUX1

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC38A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 5.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A5 gene in coronary artery disease condition [2]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC38A5 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene in coronary artery disease condition [2]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the transcription of SLC38A5 gene in coronary artery disease condition, which leads to a affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A5 gene in MCF7 cells [3]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC38A5 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A5 gene in health condition [4]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC38A5 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene [5]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC38A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 5.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene [1]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC38A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 5.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene [6]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC38A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 5.

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A5 gene in melanocyte deficiency condition [7]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcriptional repressor protein YY1 (YY1) has been reported to bind to the transcription of SLC38A5 gene in melanocyte deficiency condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A5 gene in MCF7 cells [3]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC38A5 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene [5]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC38A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 5.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A5 gene in oncogenesis condition [8]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of SLC38A5 gene in oncogenesis condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene [9]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC38A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 5.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene [6]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC38A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 5.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Bone marrow; Cervix; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC38A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 5.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC38A5 gene in colorectal cancer condition [10]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC38A5 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC38A5 gene [9]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC38A5 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 5.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC38A5 gene in epithelial to mesenchymal transition condition [11]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC38A5 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.

       Transcriptional Phenomenon2

 Binding to SLC38A5 gene in health condition [12]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC38A5 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 5.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-141. (ID:ENSG00000017483)
2 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
3 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
4 Mapping of HNF4alpha target genes in intestinal epithelial cells. BMC Gastroenterol. 2009;9:68.
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
7 YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012;8(5):e1002688.
8 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
9 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
10 ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
11 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
12 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.

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