Drug Transporter (DT) Information

General Information of DT
DT ID DTD0330
Gene Name SLC38A3
Protein Name Sodium-coupled neutral amino acid transporter 3
Gene ID
10991
UniProt ID
Q99624
TCDB ID
2.A.18.6.3
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms G17; Na(+)-coupled neutral amino acid transporter 3; SLC38A3; SN1; SNAT3; Solute carrier family 38 member 3
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Function This transporter mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.
Disease(s) Short bowel syndrome [ICD-11:KB89.1]
Vitamin deficiency [ICD-11:5B55-5B7Z]
Bed wetting [ICD-11:MF50.2Y]
Endogenous Substrate(s) Asparagine; H+; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-coupled neutral amino acid transporter 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-coupled neutral amino acid transporter 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-coupled neutral amino acid transporter 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Sodium-coupled neutral amino acid transporter 3
Microbiota Influence (MBI)

(β) Post-translational Modification of Sodium-coupled neutral amino acid transporter 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-coupled neutral amino acid transporter 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-coupled neutral amino acid transporter 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-coupled neutral amino acid transporter 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-coupled neutral amino acid transporter 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-coupled neutral amino acid transporter 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           4 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Aminosalicylic acid
 Approved Drug Info Bed wetting MF50.2Y [1]
Folic acid
 Approved Drug Info Vitamin deficiency 5B55-5B7Z [2]
L-alanine
 Approved Drug Info Glioma 2A00.0 [3]
L-glutamine
 Approved Drug Info Short bowel syndrome KB89.1 [3]
References
1 Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. Biochem J. 2000 May 15;348 Pt 1:159-66.
2 Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism. Biochem Pharmacol. 1995 Jun 16;49(12):1759-67.
3 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.

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