Drug Transporter (DT) Information

General Information of DT
DT ID DTD0329
Gene Name SLC38A2
Protein Name Sodium-coupled neutral amino acid transporter 2
Gene ID
54407
UniProt ID
Q96QD8
TCDB ID
2.A.18.6.5
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms ATA2; Amino acid transporter A2; KIAA1382; PRO1068; Protein 40-9-1; SAT2; SLC38A2; SNAT2; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Ubiquitously expressed. Widely expressed inthe central nervous system with higher concentrations in caudalregions. Expressed by glutamatergic and GABAergic neurons togetherwith astrocytes and other non-neuronal cells in the cerebralcortex (at protein level).
Function This sodium-dependent amino acid transporter mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
Disease(s) Short bowel syndrome [ICD-11:KB89.1]
Endogenous Substrate(s) Amino acids; Sodium ion
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-coupled neutral amino acid transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-coupled neutral amino acid transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-coupled neutral amino acid transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium-coupled neutral amino acid transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-coupled neutral amino acid transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-coupled neutral amino acid transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-coupled neutral amino acid transporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-coupled neutral amino acid transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-coupled neutral amino acid transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-alanine
 Approved Drug Info Glioma 2A00.0 [1]
L-glutamine
 Approved Drug Info Short bowel syndrome KB89.1 [1]
References
1 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.

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