Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0329 Transporter Info
Gene Name	SLC38A2
Transporter Name	Sodium-coupled neutral amino acid transporter 2
Gene ID	54407
UniProt ID	Q96QD8

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	motexafin gadolinium affects the reaction Zinc Acetate results in increased expression of SLC38A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Zinc Acetate affects the reaction motexafin gadolinium results in increased expression of SLC38A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol affects the expression of SLC38A2 mRNA		[58]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of SLC38A2 mRNA		[71]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid results in decreased methylation of SLC38A2 gene		[72]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Palmitic Acid co-treated with Arsenic affects the expression of SLC38A2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
1-Methyl-3-isobutylxanthine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of SLC38A2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
2-xylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-xylene results in increased expression of SLC38A2 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC38A2 protein		[34]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SLC38A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC38A2 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC38A2 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
Acrolein	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC38A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC38A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
alpha-pinene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC38A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC38A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate results in decreased expression of SLC38A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC38A2 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite results in decreased expression of SLC38A2 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC38A2 promoter		[44]
Regulation Mechanism			Transcription Factor Info
Benztropine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cuprizone co-treated with Benztropine results in increased expression of SLC38A2 protein		[45]
Regulation Mechanism			Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC38A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of SLC38A2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
bufotalin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bufotalin results in increased expression of SLC38A2 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC38A2 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
celastrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	celastrol results in decreased expression of SLC38A2 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC38A2 gene		[51]
Regulation Mechanism			Transcription Factor Info
chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chloropicrin affects the expression of SLC38A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
corosolic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	corosolic acid results in increased expression of SLC38A2 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
Cuprizone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cuprizone co-treated with Benztropine results in increased expression of SLC38A2 protein		[45]
Regulation Mechanism			Transcription Factor Info
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of SLC38A2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
Dichlorodiphenyl Dichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene results in decreased expression of SLC38A2 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
Dichlororibofuranosylbenzimidazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dichlororibofuranosylbenzimidazole affects the expression of SLC38A2 protein		[53]
Regulation Mechanism			Transcription Factor Info
Diuron	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diuron results in decreased expression of SLC38A2 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC38A2 mRNA affects the susceptibility to Doxorubicin		[55]
Regulation Mechanism			Transcription Factor Info
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dronabinol results in decreased susceptibility to Potassium Chloride which results in increased expression of SLC38A2 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
erucylphospho-N,N,N-trimethylpropylammonium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	erucylphospho-N,N,N-trimethylpropylammonium results in increased expression of SLC38A2 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
ethylbenzene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ethylbenzene results in increased expression of SLC38A2 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
ferrous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ferrous chloride results in decreased expression of SLC38A2 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
Fluoxetine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fluoxetine results in increased expression of SLC38A2 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in increased phosphorylation of SLC38A2 protein		[61]
Regulation Mechanism			Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in increased expression of SLC38A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in increased expression of SLC38A2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K 7174 results in increased expression of SLC38A2 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
LDN 193189	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC38A2 protein		[34]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC38A2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC38A2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
methacrylaldehyde	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC38A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC38A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
Methylene Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methylene Chloride results in increased expression of SLC38A2 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in increased expression of SLC38A2 mRNA		[62]
Regulation Mechanism			Transcription Factor Info
monomethylarsonous acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	monomethylarsonous acid results in increased expression of SLC38A2 protein		[63]
Regulation Mechanism			Transcription Factor Info
motexafin gadolinium	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	motexafin gadolinium affects the reaction Zinc Acetate results in increased expression of SLC38A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	motexafin gadolinium results in increased expression of SLC38A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Zinc Acetate affects the reaction motexafin gadolinium results in increased expression of SLC38A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
Naphthoquinones	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Naphthoquinones results in increased expression of SLC38A2 mRNA		[64]
Regulation Mechanism			Transcription Factor Info
Ozone	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of SLC38A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of SLC38A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Volatile Organic Compounds co-treated with Ozone affects the expression of SLC38A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
PCI 5002	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC38A2 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
perfluorooctane sulfonic acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in decreased expression of SLC38A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	perfluorooctane sulfonic acid results in increased expression of SLC38A2 mRNA		[67]
Regulation Mechanism			Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in decreased expression of SLC38A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
pinosylvin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pinosylvin results in increased expression of SLC38A2 mRNA		[68]
Regulation Mechanism			Transcription Factor Info
Potassium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dronabinol results in decreased susceptibility to Potassium Chloride which results in increased expression of SLC38A2 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of SLC38A2 mRNA		[69]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC38A2 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC38A2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC38A2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium arsenite results in increased expression of SLC38A2 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC38A2 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A inhibits the reaction Nickel affects the expression of SLC38A2 mRNA		[65]
Regulation Mechanism			Transcription Factor Info
Zinc	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC38A2 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in decreased methylation of SLC38A2 gene		[39]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Sulindac	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sulindac increases the expression of SLC38A2		[1]
Zinc Acetate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc Acetate increases the expression of SLC38A2		[2]
Raloxifene Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride increases the expression of SLC38A2		[3]
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Progesterone increases the expression of SLC38A2		[4]
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC38A2		[5]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of SLC38A2		[6]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC38A2		[7]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the expression of SLC38A2		[8]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC38A2		[9]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of SLC38A2		[10]
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin increases the expression of SLC38A2		[11]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane increases the expression of SLC38A2		[12]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC38A2		[13]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC38A2		[14]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC38A2		[15]
Drug in Phase 3 Trial
Arsenic disulfide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic disulfide increases the expression of SLC38A2		[17]
Drug in Phase 2 Trial
Motexafin gadolinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Motexafin gadolinium increases the expression of SLC38A2		[2]
Trichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichloroethylene increases the expression of SLC38A2		[18]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A affects the expression of SLC38A2		[27]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC38A2		[16]
Regulation Mechanism	via enhancement of Cyclic AMP-dependent transcription factor ATF-4 (ATF4)		Transcription Factor Info
Cell System	Human kidney human embryonic kidney 293T cells (HEK 293T)
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC38A2		[19]
Palmitic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid affects the expression of SLC38A2		[31]
Investigative Drug
[3H]Alanine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	[3H]Alanine modulates the activity of SLC38A2		[32]
Patented Pharmaceutical Agent
K-7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K-7174 increases the expression of SLC38A2		[21]
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG-001 increases the expression of SLC38A2		[23]
Natural Product
Thapsigargin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thapsigargin increases the expression of SLC38A2		[26]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC38A2		[30]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Caffeine affects the phosphorylation of SLC38A2 protein		[49]
Regulation Mechanism			Transcription Factor Info
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Jinfukang inhibits the expression of SLC38A2		[25]
Acute Toxic Substance
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Formaldehyde increases the expression of SLC38A2		[20]
Chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chloropicrin affects the expression of SLC38A2		[24]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide increases the expression of SLC38A2		[28]
Carcinogen
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate increases the expression of SLC38A2		[20]
Arsenic	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid co-treated with Arsenic affects the expression of SLC38A2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC38A2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC38A2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
Benzene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzene results in increased expression of SLC38A2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium affects the expression of SLC38A2 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Nickel	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel affects the expression of SLC38A2 mRNA		[65]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A inhibits the reaction Nickel affects the expression of SLC38A2 mRNA		[65]
Regulation Mechanism			Transcription Factor Info
Health and Environmental Toxicant
Dichloromethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dichloromethane increases the expression of SLC38A2		[18]
Ethyl benzene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl benzene increases the expression of SLC38A2		[18]
Toluene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Toluene increases the expression of SLC38A2		[18]
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate increases the expression of SLC38A2		[22]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the expression of SLC38A2		[29]

References
1	Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
2	Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
3	Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature. Mol Pharmacol. 2006 May;69(5):1615-23.
4	Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
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