Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0329 Transporter Info
Gene Name	SLC38A2
Transporter Name	Sodium-coupled neutral amino acid transporter 2
Gene ID	54407
UniProt ID	Q96QD8

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ATF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in health condition			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-4		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	up regulating
Experimental Material	Human kidney human embryonic kidney 293T cells (HEK 293T)
Detailed Description	Cyclic AMP-dependent transcription factor ATF-4 (ATF4), influenced by the exogenous sodium arsenite, has been reported to activate the transcription of SLC38A2 gene in health condition , which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone marrow; Brain; Breast; Cervix; Colon; Coronary artery; Embryo; Liver; Lung; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
MAFK		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Transcription factor MafK		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor MafK (MAFK) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 15 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in breast cancer condition			[6]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC38A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
ARNT		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in breast cancer condition			[6]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Affected Drug/Substrate	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC38A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
EPAS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in breast cancer condition			[7]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	Up regulating
Experimental Material	BALB/c athymic Nu/Nu mice
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to activate the transcription of SLC38A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
HIF1A		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene			[8]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to bind to the transcription of SLC38A2 gene in . condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Activation of SLC38A2 gene in breast cancer condition			[7]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	Up regulating
Experimental Material	BALB/c athymic Nu/Nu mice
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC38A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in melanoma condition			[9]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC38A2 gene in melanoma condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
MLXIPL		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC38A2 gene in obesity condition			[10]
TF Protein Name	Carbohydrate-responsive element-binding protein		Transcription Factor Info
Studied Phenotype	Obesity [ICD11: 5B81]
Tissue	Liver
Related DT Changes	Down regulating
Experimental Material	Wistar rats
Detailed Description	Carbohydrate-responsive element-binding protein (MLXIPL) has been reported to repress the transcription of SLC38A2 gene in obesity condition, which leads to a decreased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
MNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Max-binding protein MNT		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-binding protein MNT (MNT) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC38A2 gene in Burkitt lymphoma condition			[11]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC38A2 gene in Burkitt lymphoma condition, which leads to a decreased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Embryo; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene in coronary artery disease condition			[12]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 21 (TCF21) has been reported to bind to the SLC38A2 gene in coronary artery disease condition, which leads to a affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
USF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Upstream stimulatory factor 2		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 2 (USF2) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in MCF7 cells			[13]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC38A2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in prostate cancer condition			[14]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC38A2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in health condition			[15]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC38A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
NR1H3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in atherosclerotic foam cells condition			[16]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLC38A2 gene in atherosclerotic foam cells condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC38A2 gene in myofibroblast condition			[17]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC38A2 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
VDR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in health condition			[18]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC38A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Binding to SLC38A2 gene in THP1 cells			[19]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC38A2 gene in THP1 cells, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in megakaryocytes condition			[20]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC38A2 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
GATA3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in breast cancer condition			[21]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC38A2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Tissue	Blood; Brain; Breast; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
GATA4		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in gastric cancer condition			[22]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Affected Drug/Substrate	Metformin
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC38A2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Tissue	Heart
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor GATA-4 (GATA4) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Tissue	Blood; Tonsil
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
KLF5		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in gastric cancer condition			[22]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC38A2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
PEG3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC38A2 gene in health condition			[23]
TF Protein Name	Paternally-expressed gene 3 protein		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	Down regulating
Experimental Material	C57BL/6J mice
Detailed Description	Paternally-expressed gene 3 protein (PEG3) has been reported to repress the transcription of SLC38A2 gene in health condition, which leads to a decreased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
VEZF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Vascular endothelial zinc finger 1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Vascular endothelial zinc finger 1 (VEZF1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in breast cancer condition			[24]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC38A2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
NANOG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Homeobox protein NANOG		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein NANOG (NANOG) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
ONECUT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 6		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 6 (ONECUT1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
OTX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Homeobox protein OTX2		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein OTX2 (OTX2) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Brain; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class3.2: Paired box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PAX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Paired box protein Pax-5		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Paired box protein Pax-5 (PAX5) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in MCF7 cells			[13]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC38A2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
E2F4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in health condition			[25]
TF Protein Name	Transcription factor E2F4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC38A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Colon; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
FOXA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in prostate carcinoma condition			[26]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC38A2 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in health condition			[15]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC38A2 gene in health condition, which leads to a affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in breast cancer condition			[27]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC38A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
FOXP1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC38A2 gene in embryonic stem cell condition			[28]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC38A2 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Blood; Colon; Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 11 TF(s) Regulating This DT
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in hypoxia condition			[29]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC38A2 gene in hypoxia condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
ERG		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in oncogenesis condition			[30]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcriptional regulator ERG (ERG) has been reported to bind to the transcription of SLC38A2 gene in oncogenesis condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
ETV1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	ETS translocation variant 1		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS translocation variant 1 (ETV1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Bone marrow; Breast; Liver; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
IRF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Interferon regulatory factor 4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 4 (IRF4) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
SPIB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Transcription factor Spi-B		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Spi-B (SPIB) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in colorectal cancer condition			[31]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC38A2 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Binding to SLC38A2 gene in health condition			[32]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to bind to the transcription of SLC38A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
NFAT5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in amino acid deprivation condition			[33]
TF Protein Name	Nuclear factor of activated T-cells 5		Transcription Factor Info
Studied Phenotype	Amino acid deprivation [ICD11: 5C50]
Tissue	Spleen
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear factor of activated T-cells 5 (NFAT5) has been reported to activate the transcription of SLC38A2 gene in amino acid deprivation condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in lung adenocarcinoma condition			[34]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Affected Drug/Substrate	Glutamine
Studied Phenotype	Lung adenocarcinoma [ICD11: 2C25.0]
Tissue	Lung
Related DT Changes	Up regulating
Experimental Material	human lung adenocarcinoma associated fibroblast isolates
Detailed Description	Transcription factor p65 (RELA) has been reported to activate the transcription of SLC38A2 gene in lung adenocarcinoma condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in health condition			[35]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC38A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in epithelial to mesenchymal transition condition			[36]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC38A2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in health condition			[37]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC38A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Binding to SLC38A2 gene in megakaryocytes condition			[20]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC38A2 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in prostate cancer condition			[38]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC38A2 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
GRHL3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[2]
TF Protein Name	Grainyhead-like protein 3 homolog		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[5]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Blood; Brain; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
SMAD3		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC38A2 gene in human embryonic stem cells (hESCs) condition			[39]
TF Protein Name	Mothers against decapentaplegic homolog 3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of SLC38A2 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Binding to SLC38A2 gene in HaCaT keratinocytes condition			[40]
TF Protein Name	Mothers against decapentaplegic homolog 3		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of SLC38A2 gene in HaCaT keratinocytes condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon3	Direct binding to SLC38A2 gene			[4]
TF Protein Name	Mothers against decapentaplegic homolog 3		Transcription Factor Info
Tissue	Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Mothers against decapentaplegic homolog 3 (SMAD3) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.
SMAD4		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC38A2 gene in epithelial ovarian cancer condition			[41]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC38A2 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
Transcriptional Phenomenon2	Activation of SLC38A2 gene in hESCs condition			[39]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC38A2 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Sodium-coupled neutral amino acid transporter 2.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC38A2 gene			[3]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the SLC38A2 gene, which in turn affects the expression or function of the drug transporter Sodium-coupled neutral amino acid transporter 2.

References
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11	Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One. 2011;6(11):e26837.
12	Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
13	A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
14	Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
15	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
16	Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res. 2013;41(6):3518-31.
17	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
18	Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. BMC Med. 2013;11:163.
19	Patterns of genome-wide VDR locations. PLoS One. 2014;9(4):e96105.
20	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
21	Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
22	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
23	DNA-Binding Motif of the Imprinted Transcription Factor PEG3. PLoS One. 2015 Dec 21;10(12):e0145531.
24	Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
25	Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
26	SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
27	FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
28	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
29	The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
30	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
31	ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
32	Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
33	The osmoprotective function of the NFAT5 transcription factor in T cell development and activation. J Immunol. 2002 Nov 15;169(10):5477-88.
34	Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma. J Hematol Oncol. 2022 Oct 8;15(1):141.
35	Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle. 2011;10(24):4237-49.
36	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
37	Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 2007;21(15):1882-94.
38	Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
39	Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.
40	Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.
41	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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