Drug Transporter (DT) Information

General Information of DT
DT ID DTD0326
Gene Name SLC38A1
Protein Name Sodium-coupled neutral amino acid transporter 1
Gene ID
81539
UniProt ID
Q9H2H9
TCDB ID
2.A.18.6.14
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms ATA1; Amino acid transporter A1; N-system amino acid transporter 2; NAT2; SLC38A1; SNAT1; Solute carrier family 38 member 1; System A amino acid transporter 1; System N amino acid transporter 1
DT Family Amino Acid/Auxin Permease (AAAP) Family ;
Tissue Specificity Expressed in the cerebral cortex by pyramidaland GABAergic neurons, astrocytes and other non-neuronal cells (atprotein level). Expressed in placenta, heart, lung, skeletalmuscle, spleen, stomach and testis.
Function This sodium-dependent amino acid transporter mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
Disease(s) Short bowel syndrome [ICD-11:KB89.1]
Endogenous Substrate(s) Glutamine; Sodium ions; Zwitterionic amino acids; Aliphatic amino acids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-coupled neutral amino acid transporter 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-coupled neutral amino acid transporter 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-coupled neutral amino acid transporter 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium-coupled neutral amino acid transporter 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-coupled neutral amino acid transporter 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-coupled neutral amino acid transporter 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-coupled neutral amino acid transporter 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-coupled neutral amino acid transporter 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-coupled neutral amino acid transporter 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-alanine
 Approved Drug Info Glioma 2A00.0 [1]
L-glutamine
 Approved Drug Info Short bowel syndrome KB89.1 [1]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Alanine
5950
EM Info Identified using SNAT1 knockout T-cells [2]
References
1 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.
2 Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef. Cell Host Microbe. 2015 Oct 14;18(4):409-23.

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