| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0529 | ||||
| Gene Name | SCN9A | ||||
| Protein Name | Voltage-gated sodium channel alpha Nav1.7 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6J8G_A_A Identity:99.33% Minimized Score:-3418.806 kcal/mol Detail: Structure Info |
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| Synonyms | ETHA; FEB3B; GEFSP7; HSAN2D; NE-NA; NENA; Nav1.7; Neuroendocrine sodium channel; PN1; Peripheral sodium channel 1; SCN9A; SFNP; Sodium channel protein type IX subunit alpha; Sodium channel protein type 9 subunit alpha; hNE-Na; Voltage-gated sodium channel subunit alpha Nav1.7 | ||||
| DT Family | Voltage-Gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Expressed strongly in dorsal root ganglion,with only minor levels elsewhere in the body, smooth muscle cells,MTC cell line and C-cell carcinoma. Isoform 1 is expressedpreferentially in the central and peripheral nervous system.Isoform 2 is expressed preferentially in the dorsal root ganglion. | ||||
| Function | This transporter plays a role in inflammatory pain mechanisms and mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform). | ||||
| Endogenous Substrate(s) | Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-gated sodium channel alpha Nav1.7 |
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(β) Cell Distribution Level of Voltage-gated sodium channel alpha Nav1.7 |
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(γ) Organelle Distribution Level of Voltage-gated sodium channel alpha Nav1.7 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-gated sodium channel alpha Nav1.7 |
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(γ) Transcriptional Regulation of Voltage-gated sodium channel alpha Nav1.7 |
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(δ) Epigenetic Regulation of Voltage-gated sodium channel alpha Nav1.7 |
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(ε) Exogenous Modulation of Voltage-gated sodium channel alpha Nav1.7 |
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Structural Variability Data of This DT |
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(α) Mutation-induced Structural Variation |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-gated sodium channel alpha Nav1.7 |
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(β) Disease-specific Protein Abundances of Voltage-gated sodium channel alpha Nav1.7 |
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(γ) Species- and Tissue-specific DT Abundances |
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