Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0529 Transporter Info | ||||
| Gene Name | SCN9A | ||||
| Protein Name | Voltage-gated sodium channel alpha Nav1.7 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs6746030 | ||||
| Site of GPD | chr2:166242648 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>G | ||||
| Minor Allele Frequency | A=0.0978/438 (Global) | ||||
| Allele G | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Opioids | N.A. | Death | Allele G is not associated with risk of Death due to opioids in people with Opioid-Related Disorders as compared to allele A. | [ 1] | |
| Allele A | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Botulinum Toxin Type A | N.A. | Death | Allele A is not associated with response to botulinum toxin type a in women with Migraine NOS as compared to allele G. | [ 2] | |
| Genotypes AA + AG | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Propofol | N.A. | Death | Genotypes AA + AG are associated with increased response to propofol as compared to genotype GG. | [ 3] | |
| Propofol | Drug Info | . | Correlated with the increased drug response (compare with genotype GG) | [ 3] | |
| Genetic Polymorphism | rs41268673 | ||||
| Site of GPD | chr2:166284599 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | G>C / G>T | ||||
| Minor Allele Frequency | G=0.9870/1953 (Global) | ||||
| Allele T | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Opioids | N.A. | Death | Allele T is not associated with risk of Death due to opioids in people with Opioid-Related Disorders as compared to allele G. | [ 1] | |
| References | |||||
| 1 | The ABCB1, rs9282564, AG and TT Genotypes and the COMT, rs4680, AA Genotype are Less Frequent in Deceased Patients with Opioid Addiction than in Living Patients with Opioid Addiction. Basic Clin Pharmacol Toxicol. 2016 Oct;119(4):381-8. | ||||
| 2 | CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA. J Headache Pain. 2019 Apr 23;20(1):39. | ||||
| 3 | Association of Polymorphisms in Pharmacogenetic Candidate Genes with Propofol Susceptibility. Sci Rep. 2017 Jun 13;7(1):3343. | ||||
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