Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0529 Transporter Info
Gene Name	SCN9A
Transporter Name	Voltage-gated sodium channel alpha Nav1.7
Gene ID	6335
UniProt ID	Q15858

Epigenetic Regulations of This DT (EGR)
Methylation
Bladder cancer	9 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in bladder cancer			[ 1 ]
Location	5'UTR (cg19098619)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-2.33E+00	Statistic Test	p-value:5.18E-13; Z-score:-1.64E+01
Methylation in Case	3.05E-01 (Median)	Methylation in Control	7.11E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in bladder cancer			[ 1 ]
Location	5'UTR (cg13425422)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.36E+00	Statistic Test	p-value:5.35E-06; Z-score:-1.28E+01
Methylation in Case	6.31E-01 (Median)	Methylation in Control	8.56E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in bladder cancer			[ 1 ]
Location	5'UTR (cg18745035)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.20E+00	Statistic Test	p-value:5.53E-06; Z-score:-6.55E+00
Methylation in Case	7.55E-01 (Median)	Methylation in Control	9.04E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in bladder cancer			[ 1 ]
Location	5'UTR (cg01790523)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.87E+00	Statistic Test	p-value:5.71E-04; Z-score:-4.01E+00
Methylation in Case	2.54E-01 (Median)	Methylation in Control	4.73E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in bladder cancer			[ 1 ]
Location	5'UTR (cg14794191)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.14E+00	Statistic Test	p-value:7.04E-04; Z-score:-4.62E+00
Methylation in Case	7.64E-01 (Median)	Methylation in Control	8.70E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SCN9A in bladder cancer			[ 1 ]
Location	TSS1500 (cg02056098)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.24E+00	Statistic Test	p-value:4.68E-03; Z-score:-2.19E+00
Methylation in Case	5.10E-01 (Median)	Methylation in Control	6.31E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SCN9A in bladder cancer			[ 1 ]
Location	Body (cg27357229)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.99E+00	Statistic Test	p-value:4.19E-08; Z-score:-7.61E+00
Methylation in Case	3.53E-01 (Median)	Methylation in Control	7.02E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon8	Methylation of SCN9A in bladder cancer			[ 1 ]
Location	Body (cg19320612)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.27E+00	Statistic Test	p-value:7.54E-06; Z-score:-1.73E+01
Methylation in Case	6.95E-01 (Median)	Methylation in Control	8.80E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon9	Methylation of SCN9A in bladder cancer			[ 1 ]
Location	Body (cg07296661)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.17E+00	Statistic Test	p-value:2.17E-05; Z-score:-8.16E+00
Methylation in Case	7.45E-01 (Median)	Methylation in Control	8.75E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Breast cancer	16 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in breast cancer			[ 2 ]
Location	5'UTR (cg01790523)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.48E+00	Statistic Test	p-value:1.95E-12; Z-score:-2.89E+00
Methylation in Case	3.09E-01 (Median)	Methylation in Control	4.57E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in breast cancer			[ 2 ]
Location	5'UTR (cg13425422)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.15E+00	Statistic Test	p-value:9.60E-11; Z-score:-2.69E+00
Methylation in Case	7.35E-01 (Median)	Methylation in Control	8.43E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in breast cancer			[ 2 ]
Location	5'UTR (cg14794191)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.08E+00	Statistic Test	p-value:7.57E-08; Z-score:-1.43E+00
Methylation in Case	7.91E-01 (Median)	Methylation in Control	8.54E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in breast cancer			[ 2 ]
Location	5'UTR (cg18745035)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.06E+00	Statistic Test	p-value:1.66E-07; Z-score:-1.11E+00
Methylation in Case	8.48E-01 (Median)	Methylation in Control	8.98E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in breast cancer			[ 2 ]
Location	5'UTR (cg03466415)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.02E+00	Statistic Test	p-value:4.98E-05; Z-score:-6.34E-01
Methylation in Case	8.10E-01 (Median)	Methylation in Control	8.27E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SCN9A in breast cancer			[ 2 ]
Location	5'UTR (cg19098619)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.05E+00	Statistic Test	p-value:4.82E-02; Z-score:-3.43E-01
Methylation in Case	4.28E-01 (Median)	Methylation in Control	4.50E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SCN9A in breast cancer			[ 2 ]
Location	TSS1500 (cg22199615)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.42E+00	Statistic Test	p-value:8.89E-05; Z-score:1.03E+00
Methylation in Case	1.29E-01 (Median)	Methylation in Control	9.03E-02 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon8	Methylation of SCN9A in breast cancer			[ 2 ]
Location	TSS1500 (cg24789128)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.02E+00	Statistic Test	p-value:1.47E-04; Z-score:-7.86E-02
Methylation in Case	8.78E-02 (Median)	Methylation in Control	8.91E-02 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon9	Methylation of SCN9A in breast cancer			[ 2 ]
Location	TSS1500 (cg02642021)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.02E+00	Statistic Test	p-value:2.98E-03; Z-score:6.21E-02
Methylation in Case	1.26E-01 (Median)	Methylation in Control	1.24E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon10	Methylation of SCN9A in breast cancer			[ 2 ]
Location	TSS1500 (cg02056098)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.09E+00	Statistic Test	p-value:6.84E-03; Z-score:8.18E-01
Methylation in Case	7.16E-01 (Median)	Methylation in Control	6.56E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon11	Methylation of SCN9A in breast cancer			[ 2 ]
Location	TSS200 (cg22528044)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.67E+00	Statistic Test	p-value:2.72E-04; Z-score:6.51E-01
Methylation in Case	3.21E-02 (Median)	Methylation in Control	1.93E-02 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon12	Methylation of SCN9A in breast cancer			[ 2 ]
Location	TSS200 (cg18047082)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.23E+00	Statistic Test	p-value:4.07E-03; Z-score:6.35E-01
Methylation in Case	5.49E-02 (Median)	Methylation in Control	4.48E-02 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon13	Methylation of SCN9A in breast cancer			[ 2 ]
Location	TSS200 (cg00394494)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.09E+00	Statistic Test	p-value:4.78E-02; Z-score:6.05E-02
Methylation in Case	1.53E-02 (Median)	Methylation in Control	1.40E-02 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon14	Methylation of SCN9A in breast cancer			[ 2 ]
Location	Body (cg19320612)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.06E+00	Statistic Test	p-value:1.45E-06; Z-score:-1.43E+00
Methylation in Case	8.03E-01 (Median)	Methylation in Control	8.53E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon15	Methylation of SCN9A in breast cancer			[ 2 ]
Location	Body (cg07296661)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.05E+00	Statistic Test	p-value:1.76E-05; Z-score:-9.20E-01
Methylation in Case	7.60E-01 (Median)	Methylation in Control	7.98E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon16	Methylation of SCN9A in breast cancer			[ 2 ]
Location	Body (cg27357229)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.22E+00	Statistic Test	p-value:3.79E-05; Z-score:-1.77E+00
Methylation in Case	4.85E-01 (Median)	Methylation in Control	5.94E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Colon cancer	6 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in colon adenocarcinoma			[ 3 ]
Location	5'UTR (cg06645921)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.09E+00	Statistic Test	p-value:9.68E-04; Z-score:6.13E-01
Methylation in Case	5.88E-01 (Median)	Methylation in Control	5.41E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in colon adenocarcinoma			[ 3 ]
Location	TSS1500 (cg15083845)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.04E+00	Statistic Test	p-value:4.85E-03; Z-score:-1.10E+00
Methylation in Case	7.74E-01 (Median)	Methylation in Control	8.04E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in colon adenocarcinoma			[ 3 ]
Location	TSS200 (cg03240509)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.16E+00	Statistic Test	p-value:2.60E-03; Z-score:2.10E+00
Methylation in Case	5.76E-01 (Median)	Methylation in Control	4.95E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in colon adenocarcinoma			[ 3 ]
Location	Body (cg26572770)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.20E+00	Statistic Test	p-value:1.96E-04; Z-score:1.45E+00
Methylation in Case	6.52E-01 (Median)	Methylation in Control	5.44E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in colon adenocarcinoma			[ 3 ]
Location	Body (cg07223937)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.02E+00	Statistic Test	p-value:1.59E-03; Z-score:-1.16E+00
Methylation in Case	8.66E-01 (Median)	Methylation in Control	8.85E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SCN9A in colon adenocarcinoma			[ 3 ]
Location	Body (cg16909495)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.28E+00	Statistic Test	p-value:3.52E-03; Z-score:2.53E+00
Methylation in Case	5.18E-01 (Median)	Methylation in Control	4.04E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Colorectal cancer	13 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	5'UTR (cg01790523)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.55E+00	Statistic Test	p-value:3.79E-20; Z-score:-4.57E+00
Methylation in Case	4.60E-01 (Median)	Methylation in Control	7.13E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	5'UTR (cg19098619)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.45E+00	Statistic Test	p-value:6.42E-18; Z-score:-5.69E+00
Methylation in Case	5.92E-01 (Median)	Methylation in Control	8.59E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	5'UTR (cg13425422)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.20E+00	Statistic Test	p-value:3.41E-13; Z-score:-7.75E+00
Methylation in Case	7.59E-01 (Median)	Methylation in Control	9.11E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	5'UTR (cg14794191)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.15E+00	Statistic Test	p-value:4.92E-11; Z-score:-5.95E+00
Methylation in Case	8.02E-01 (Median)	Methylation in Control	9.21E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	5'UTR (cg03466415)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.00E+00	Statistic Test	p-value:2.62E-03; Z-score:-1.86E-02
Methylation in Case	9.30E-01 (Median)	Methylation in Control	9.30E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	5'UTR (cg18745035)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.04E+00	Statistic Test	p-value:5.85E-03; Z-score:-3.40E-01
Methylation in Case	8.86E-01 (Median)	Methylation in Control	9.21E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	TSS1500 (cg24789128)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.16E+00	Statistic Test	p-value:1.61E-04; Z-score:7.66E-01
Methylation in Case	1.02E-01 (Median)	Methylation in Control	8.81E-02 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon8	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	TSS1500 (cg02642021)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.06E+00	Statistic Test	p-value:9.81E-04; Z-score:2.83E-01
Methylation in Case	1.74E-01 (Median)	Methylation in Control	1.65E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon9	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	TSS1500 (cg22199615)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.07E+00	Statistic Test	p-value:2.69E-03; Z-score:2.17E-01
Methylation in Case	8.51E-02 (Median)	Methylation in Control	7.97E-02 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon10	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	Body (cg27357229)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.37E+00	Statistic Test	p-value:7.95E-16; Z-score:-6.01E+00
Methylation in Case	5.76E-01 (Median)	Methylation in Control	7.88E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon11	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	Body (cg07296661)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.14E+00	Statistic Test	p-value:8.13E-12; Z-score:-9.46E+00
Methylation in Case	8.17E-01 (Median)	Methylation in Control	9.31E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon12	Methylation of SCN9A in colorectal cancer			[ 4 ]
Location	Body (cg19320612)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.09E+00	Statistic Test	p-value:1.31E-09; Z-score:-4.39E+00
Methylation in Case	8.51E-01 (Median)	Methylation in Control	9.26E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Hepatocellular carcinoma	15 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	5'UTR (cg01790523)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.12E+00	Statistic Test	p-value:2.97E-04; Z-score:-6.52E-01
Methylation in Case	4.51E-01 (Median)	Methylation in Control	5.06E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	5'UTR (cg00612138)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.08E+00	Statistic Test	p-value:7.39E-03; Z-score:-3.91E-01
Methylation in Case	5.93E-02 (Median)	Methylation in Control	6.41E-02 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	5'UTR (cg03466415)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.00E+00	Statistic Test	p-value:1.23E-02; Z-score:-1.62E-01
Methylation in Case	8.42E-01 (Median)	Methylation in Control	8.45E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	TSS1500 (cg02067405)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:2.29E+00	Statistic Test	p-value:1.64E-13; Z-score:5.47E+00
Methylation in Case	3.88E-01 (Median)	Methylation in Control	1.70E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	TSS1500 (cg24314549)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.24E+00	Statistic Test	p-value:2.46E-10; Z-score:-1.27E+00
Methylation in Case	1.68E-01 (Median)	Methylation in Control	2.08E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	TSS1500 (cg02056098)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.07E+00	Statistic Test	p-value:1.29E-03; Z-score:8.71E-01
Methylation in Case	7.93E-01 (Median)	Methylation in Control	7.39E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	TSS1500 (cg02642021)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.01E+00	Statistic Test	p-value:2.56E-03; Z-score:-7.26E-02
Methylation in Case	1.08E-01 (Median)	Methylation in Control	1.10E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon8	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	TSS1500 (cg22199615)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.04E+00	Statistic Test	p-value:6.33E-03; Z-score:1.07E-01
Methylation in Case	7.62E-02 (Median)	Methylation in Control	7.31E-02 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon9	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	TSS1500 (cg24789128)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.00E+00	Statistic Test	p-value:8.79E-03; Z-score:-9.17E-05
Methylation in Case	6.00E-02 (Median)	Methylation in Control	6.00E-02 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon10	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	Body (cg03922758)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.70E+00	Statistic Test	p-value:3.21E-18; Z-score:-1.37E+01
Methylation in Case	4.69E-01 (Median)	Methylation in Control	7.96E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon11	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	Body (cg16287284)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.67E+00	Statistic Test	p-value:3.91E-15; Z-score:-3.70E+00
Methylation in Case	3.36E-01 (Median)	Methylation in Control	5.61E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon12	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	Body (cg08382534)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.25E+00	Statistic Test	p-value:9.36E-13; Z-score:-3.58E+00
Methylation in Case	6.68E-01 (Median)	Methylation in Control	8.32E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon13	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	Body (cg19062099)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.41E+00	Statistic Test	p-value:9.12E-11; Z-score:-1.78E+00
Methylation in Case	2.54E-01 (Median)	Methylation in Control	3.59E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon14	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	Body (cg07296661)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.03E+00	Statistic Test	p-value:3.30E-04; Z-score:-8.74E-01
Methylation in Case	8.26E-01 (Median)	Methylation in Control	8.50E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon15	Methylation of SCN9A in hepatocellular carcinoma			[ 5 ]
Location	Body (cg27357229)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.06E+00	Statistic Test	p-value:1.15E-02; Z-score:-5.96E-01
Methylation in Case	6.21E-01 (Median)	Methylation in Control	6.60E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Lung adenocarcinoma	8 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in lung adenocarcinoma			[ 6 ]
Location	5'UTR (cg19098619)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.14E+00	Statistic Test	p-value:4.08E-03; Z-score:-1.96E+00
Methylation in Case	6.63E-01 (Median)	Methylation in Control	7.55E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in lung adenocarcinoma			[ 6 ]
Location	5'UTR (cg14794191)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.03E+00	Statistic Test	p-value:1.71E-02; Z-score:-1.31E+00
Methylation in Case	8.52E-01 (Median)	Methylation in Control	8.79E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in lung adenocarcinoma			[ 6 ]
Location	5'UTR (cg01790523)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.08E+00	Statistic Test	p-value:2.11E-02; Z-score:-1.03E+00
Methylation in Case	4.91E-01 (Median)	Methylation in Control	5.31E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in lung adenocarcinoma			[ 6 ]
Location	5'UTR (cg13425422)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.04E+00	Statistic Test	p-value:4.10E-02; Z-score:-2.54E+00
Methylation in Case	8.46E-01 (Median)	Methylation in Control	8.81E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in lung adenocarcinoma			[ 6 ]
Location	TSS1500 (cg02056098)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.20E+00	Statistic Test	p-value:1.89E-05; Z-score:2.70E+00
Methylation in Case	8.06E-01 (Median)	Methylation in Control	6.70E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SCN9A in lung adenocarcinoma			[ 6 ]
Location	TSS1500 (cg24789128)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.27E+00	Statistic Test	p-value:3.72E-02; Z-score:2.35E+00
Methylation in Case	1.14E-01 (Median)	Methylation in Control	9.03E-02 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SCN9A in lung adenocarcinoma			[ 6 ]
Location	TSS200 (cg00394494)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.60E+00	Statistic Test	p-value:1.03E-02; Z-score:2.97E+00
Methylation in Case	5.05E-02 (Median)	Methylation in Control	3.15E-02 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon8	Methylation of SCN9A in lung adenocarcinoma			[ 6 ]
Location	Body (cg07296661)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.05E+00	Statistic Test	p-value:6.12E-04; Z-score:-2.16E+00
Methylation in Case	8.42E-01 (Median)	Methylation in Control	8.80E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Pancretic ductal adenocarcinoma	16 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	5'UTR (cg15759056)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:3.81E+00	Statistic Test	p-value:2.90E-33; Z-score:7.87E+00
Methylation in Case	1.82E-01 (Median)	Methylation in Control	4.77E-02 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	5'UTR (cg07969045)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.03E+00	Statistic Test	p-value:3.43E-13; Z-score:-1.40E+00
Methylation in Case	8.79E-01 (Median)	Methylation in Control	9.03E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	5'UTR (cg03861633)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.09E+00	Statistic Test	p-value:6.02E-06; Z-score:-1.07E+00
Methylation in Case	7.24E-01 (Median)	Methylation in Control	7.90E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	TSS1500 (cg23331484)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.33E+00	Statistic Test	p-value:2.92E-22; Z-score:3.31E+00
Methylation in Case	5.36E-01 (Median)	Methylation in Control	4.02E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	TSS1500 (cg18939241)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.23E+00	Statistic Test	p-value:6.07E-07; Z-score:1.65E+00
Methylation in Case	6.94E-01 (Median)	Methylation in Control	5.65E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	TSS1500 (cg04539957)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.16E+00	Statistic Test	p-value:1.34E-06; Z-score:1.46E+00
Methylation in Case	7.34E-01 (Median)	Methylation in Control	6.34E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	TSS1500 (cg04460557)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.06E+00	Statistic Test	p-value:2.41E-02; Z-score:-4.97E-01
Methylation in Case	4.63E-01 (Median)	Methylation in Control	4.88E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon8	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	1stExon (cg19561774)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.01E+00	Statistic Test	p-value:2.37E-02; Z-score:8.27E-01
Methylation in Case	8.77E-01 (Median)	Methylation in Control	8.64E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon9	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	Body (cg20669572)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.24E+00	Statistic Test	p-value:1.17E-08; Z-score:1.80E+00
Methylation in Case	6.97E-01 (Median)	Methylation in Control	5.63E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon10	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	Body (cg02057782)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.27E+00	Statistic Test	p-value:1.81E-07; Z-score:1.39E+00
Methylation in Case	5.25E-01 (Median)	Methylation in Control	4.13E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon11	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	Body (cg23301539)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.01E+00	Statistic Test	p-value:3.85E-04; Z-score:-4.19E-01
Methylation in Case	9.35E-01 (Median)	Methylation in Control	9.40E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon12	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	Body (cg08065122)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.35E+00	Statistic Test	p-value:7.13E-04; Z-score:1.42E+00
Methylation in Case	7.03E-01 (Median)	Methylation in Control	5.21E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon13	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	Body (cg17778888)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.01E+00	Statistic Test	p-value:1.26E-03; Z-score:-3.63E-01
Methylation in Case	8.94E-01 (Median)	Methylation in Control	9.06E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon14	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	Body (cg23533824)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.15E+00	Statistic Test	p-value:2.62E-02; Z-score:1.10E+00
Methylation in Case	7.41E-01 (Median)	Methylation in Control	6.43E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon15	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	Body (cg03729603)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.20E+00	Statistic Test	p-value:4.03E-02; Z-score:1.13E+00
Methylation in Case	7.42E-01 (Median)	Methylation in Control	6.19E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon16	Methylation of SCN9A in pancretic ductal adenocarcinoma			[ 7 ]
Location	3'UTR (cg20942867)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-2.84E+00	Statistic Test	p-value:8.73E-08; Z-score:-1.59E+00
Methylation in Case	1.55E-01 (Median)	Methylation in Control	4.39E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Panic disorder	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in panic disorder			[ 8 ]
Location	5'UTR (cg03466415)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.07E+00	Statistic Test	p-value:2.71E-03; Z-score:-4.40E-01
Methylation in Case	2.31E+00 (Median)	Methylation in Control	2.46E+00 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in panic disorder			[ 8 ]
Location	5'UTR (cg13425422)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.14E+00	Statistic Test	p-value:3.23E-02; Z-score:-2.55E-01
Methylation in Case	8.14E-01 (Median)	Methylation in Control	9.27E-01 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in panic disorder			[ 8 ]
Location	TSS1500 (cg24789128)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:9.71E-01	Statistic Test	p-value:2.18E-02; Z-score:5.01E-01
Methylation in Case	-5.13E+00 (Median)	Methylation in Control	-5.28E+00 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in panic disorder			[ 8 ]
Location	Body (cg27357229)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-6.10E-01	Statistic Test	p-value:5.83E-06; Z-score:-6.25E-01
Methylation in Case	-6.15E-01 (Median)	Methylation in Control	-3.75E-01 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in panic disorder			[ 8 ]
Location	Body (cg07296661)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.19E+00	Statistic Test	p-value:2.86E-04; Z-score:-7.36E-01
Methylation in Case	1.63E+00 (Median)	Methylation in Control	1.94E+00 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Papillary thyroid cancer	7 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in papillary thyroid cancer			[ 9 ]
Location	5'UTR (cg18745035)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.01E+00	Statistic Test	p-value:3.62E-03; Z-score:-4.85E-01
Methylation in Case	9.03E-01 (Median)	Methylation in Control	9.16E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in papillary thyroid cancer			[ 9 ]
Location	5'UTR (cg13425422)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.02E+00	Statistic Test	p-value:4.15E-03; Z-score:-7.15E-01
Methylation in Case	9.24E-01 (Median)	Methylation in Control	9.38E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in papillary thyroid cancer			[ 9 ]
Location	5'UTR (cg14794191)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.01E+00	Statistic Test	p-value:7.18E-03; Z-score:-5.76E-01
Methylation in Case	9.15E-01 (Median)	Methylation in Control	9.25E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in papillary thyroid cancer			[ 9 ]
Location	TSS1500 (cg02056098)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.12E+00	Statistic Test	p-value:5.96E-03; Z-score:1.06E+00
Methylation in Case	6.01E-01 (Median)	Methylation in Control	5.35E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in papillary thyroid cancer			[ 9 ]
Location	TSS1500 (cg22199615)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.04E+00	Statistic Test	p-value:3.49E-02; Z-score:2.78E-01
Methylation in Case	1.16E-01 (Median)	Methylation in Control	1.12E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SCN9A in papillary thyroid cancer			[ 9 ]
Location	Body (cg07296661)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.01E+00	Statistic Test	p-value:7.06E-03; Z-score:-3.17E-01
Methylation in Case	9.27E-01 (Median)	Methylation in Control	9.33E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SCN9A in papillary thyroid cancer			[ 9 ]
Location	Body (cg19320612)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.01E+00	Statistic Test	p-value:1.56E-02; Z-score:-3.03E-01
Methylation in Case	9.22E-01 (Median)	Methylation in Control	9.28E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Renal cell carcinoma	6 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in clear cell renal cell carcinoma			[ 10 ]
Location	TSS1500 (cg02056098)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.12E+00	Statistic Test	p-value:6.08E-03; Z-score:1.83E+00
Methylation in Case	8.00E-01 (Median)	Methylation in Control	7.12E-01 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in clear cell renal cell carcinoma			[ 10 ]
Location	TSS1500 (cg24789128)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.07E+00	Statistic Test	p-value:1.03E-02; Z-score:2.62E-01
Methylation in Case	2.85E-02 (Median)	Methylation in Control	2.66E-02 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SCN9A in clear cell renal cell carcinoma			[ 10 ]
Location	TSS1500 (cg02642021)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.06E+00	Statistic Test	p-value:3.34E-02; Z-score:1.89E-01
Methylation in Case	4.72E-02 (Median)	Methylation in Control	4.45E-02 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SCN9A in clear cell renal cell carcinoma			[ 10 ]
Location	TSS200 (cg18047082)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.17E+00	Statistic Test	p-value:1.01E-03; Z-score:1.05E+00
Methylation in Case	4.20E-02 (Median)	Methylation in Control	3.58E-02 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SCN9A in clear cell renal cell carcinoma			[ 10 ]
Location	TSS200 (cg22528044)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.07E+00	Statistic Test	p-value:1.81E-02; Z-score:4.57E-01
Methylation in Case	2.19E-02 (Median)	Methylation in Control	2.05E-02 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SCN9A in clear cell renal cell carcinoma			[ 10 ]
Location	TSS200 (cg00394494)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.07E+00	Statistic Test	p-value:2.47E-02; Z-score:4.02E-01
Methylation in Case	1.60E-02 (Median)	Methylation in Control	1.49E-02 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Prostate cancer	3 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SCN9A in prostate cancer			[ 11 ]
Location	1stExon (cg13958974)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.38E+00	Statistic Test	p-value:1.49E-02; Z-score:1.78E+00
Methylation in Case	6.42E-01 (Median)	Methylation in Control	4.64E-01 (Median)
Studied Phenotype	Prostate cancer[ ICD-11:2C82]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SCN9A in prostate cancer			[ 11 ]
Location	3'UTR (cg06885175)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.64E+00	Statistic Test	p-value:2.28E-02; Z-score:-6.16E+00
Methylation in Case	2.78E-01 (Median)	Methylation in Control	4.56E-01 (Median)
Studied Phenotype	Prostate cancer[ ICD-11:2C82]
Experimental Material	Patient tissue samples
Lymphoma	1 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Significant hypermethylation of SCN9A in lymphoma than that in healthy individual
Studied Phenotype	Lymphoma [ICD-11:2B30]
The Methylation Level of Disease Section Compare with the Healthy Individual	p-value:3.14E-25; Fold-change:0.549555105; Z-score:17.16148881
DT methylation level in the diseased tissue of patients DT methylation level in the normal tissue of healthy individuals
			Please Click the above Thumbnail to View/Download the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue Download DT methylation data in the tissue of healthy individual

References
1	DNA Methylation Dynamics in Urological Tumors.
2	Genome-wide Scan for Methylation Profiles in Breast Cancer
3	Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips. Epigenetics. 2013 Sep;8(9):921-34.
4	Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
5	Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
6	DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues
7	Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
8	DNA Methylation signatures in panic disorder. Transl Psychiatry. 2017 Dec 18;7(12):1287.
9	Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
10	A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma. Nat Commun. 2015 Oct 30;6:8699.
11	Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array. BMC Genomics. 2014 Jan 22;15:51.

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