Drug Transporter (DT) Information

General Information of DT
DT ID DTD0511
Gene Name KCNJ11
Protein Name ATP-sensitive inward rectifier potassium channel 11
Gene ID
3767
UniProt ID
Q14654
TCDB ID
1.A.2.1.17
3D Structure

Crystal Structure

Crystallisation Method:EM

PDB ID:6C3O

Corresponding Chain:A/B/C/D

Sequence Length:1-390

Detail: Struture Info

Synonyms BIR; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2; KCNJ11; KIR6.2; MODY13; PHHI; Potassium channel, inwardly rectifying subfamily J member 11; TNDM3
DT Family Inward Rectifier K(+) Channel (IRK-C) Family ;
Function This tranporter involved in growth factor signaling through its influence on the Ral signaling pathway.
Endogenous Substrate(s) Potassium ions
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of ATP-sensitive inward rectifier potassium channel 11
Tissue Distribution Level (TD)

(β) Cell Distribution Level of ATP-sensitive inward rectifier potassium channel 11
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of ATP-sensitive inward rectifier potassium channel 11
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of ATP-sensitive inward rectifier potassium channel 11
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of ATP-sensitive inward rectifier potassium channel 11
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of ATP-sensitive inward rectifier potassium channel 11
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of ATP-sensitive inward rectifier potassium channel 11
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of ATP-sensitive inward rectifier potassium channel 11
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of ATP-sensitive inward rectifier potassium channel 11
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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