General Information of Drug Transporter (DT)
DT ID	DTD0511 Transporter Info
Gene Name	KCNJ11
Protein Name	ATP-sensitive inward rectifier potassium channel 11
Gene ID	3767
UniProt ID	Q14654
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs5215
Site of GPD	chr11:17387083 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>T
Minor Allele Frequency	C=0.2680/3480 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Sulfonamides	Drug Info	Diabetes Mellitus	Irrelevant to the drug response in patients (compare with allele C)		[ 1]
Sulfonamides, Urea Derivatives	N.A.	Hypoglycemia	Allele T is not associated with response to sulfonamides, urea derivatives in people with Diabetes Mellitus as compared to allele C.		[ 1]
Allele C	Click to Show/Hide the Full List of Affected Drugs:         10 Drugs in Total
Gliclazide	N.A.	Diarrhea	Allele C is not associated with dose of glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Glimepiride	N.A.	Diarrhea	Allele C is not associated with dose of glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Glipizide	N.A.	Diarrhea	Allele C is not associated with dose of glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Gliquidone	N.A.	Diarrhea	Allele C is not associated with dose of glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Glyburide	N.A.	Diarrhea	Allele C is not associated with dose of glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Gliclazide	N.A.	Hypoglycemia	Allele C is not associated with risk of Hypoglycemia when treated with glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Glimepiride	N.A.	Hypoglycemia	Allele C is not associated with risk of Hypoglycemia when treated with glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Glipizide	N.A.	Hypoglycemia	Allele C is not associated with risk of Hypoglycemia when treated with glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Gliquidone	N.A.	Hypoglycemia	Allele C is not associated with risk of Hypoglycemia when treated with glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Glyburide	N.A.	Hypoglycemia	Allele C is not associated with risk of Hypoglycemia when treated with glibenclamide, gliclazide, glimepiride, glipizide and gliquidone in people with Diabetes Mellitus as compared to allele T.		[ 2]
Genetic Polymorphism	rs2285676
Site of GPD	chr11:17386478 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>C / A>G / A>T
Minor Allele Frequency	A=0.5360/1060 (Global)
Genotype GG	Click to Show/Hide the Full List of Affected Drugs:           4 Drugs in Total
Sitagliptin	N.A.	Diarrhea	Genotype GG is associated with increased response to sitagliptin in people with Diabetes Mellitus, Type 2.		[ 3]
Linagliptin	N.A.	Hypoglycemia	Genotype GG is associated with increased clinical benefit to linagliptin, sitagliptin or vildagliptin in people with Diabetes Mellitus, Type 2 as compared to genotypes AA + AG.		[ 4]
Sitagliptin	N.A.	Hypoglycemia	Genotype GG is associated with increased clinical benefit to linagliptin, sitagliptin or vildagliptin in people with Diabetes Mellitus, Type 2 as compared to genotypes AA + AG.		[ 4]
Vildagliptin	N.A.	Hypoglycemia	Genotype GG is associated with increased clinical benefit to linagliptin, sitagliptin or vildagliptin in people with Diabetes Mellitus, Type 2 as compared to genotypes AA + AG.		[ 4]
Genetic Polymorphism	rs587783672
Site of GPD	chr11:17387413 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>T
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Sulfonamides, Urea Derivatives	N.A.	Hypoglycemia	Allele T is associated with response to sulfonamides, urea derivatives in children as compared to allele C.		[ 5]
References
1	Genotypic and Phenotypic Factors Influencing Drug Response in Mexican Patients With Type 2 Diabetes Mellitus. Front Pharmacol. 2018 Apr 6;9:320.
2	CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients. Eur J Clin Pharmacol. 2014 Apr;70(4):421-8.
3	Comparative efficacy and safety of sitagliptin or gliclazide combined with metformin in treatment-naive patients with type 2 diabetes: A single-center, prospective, randomized, controlled, noninferiority study with genetic polymorphism analysis. Medicine (Baltimore). 2025 Jan 10;104(2):e41061.
4	Clinical and genetic predictors of dipeptidyl peptidase-4 inhibitor treatment response in Type 2 diabetes mellitus. Pharmacogenomics. 2016 Jun;17(8):867-81.
5	Detection of KCNJ11 gene mutations in a family with neonatal diabetes mellitus: implications for therapeutic management of family members with long-standing disease. Mol Diagn Ther. 2012 Apr 01;16(2):109-14.

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