Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID DTD0511 Transporter Info
Gene Name KCNJ11
Transporter Name ATP-sensitive inward rectifier potassium channel 11
Gene ID
3767
UniProt ID
Q14654
Epigenetic Regulations of This DT (EGR)

Methylation

  Bladder cancer

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of KCNJ11 in bladder cancer [ 1 ]

Location

 TSS1500 (cg23065768)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-2.16E+00 Statistic Test p-value:1.33E-09; Z-score:-7.73E+00

Methylation in Case

 2.43E-01 (Median) Methylation in Control 5.24E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of KCNJ11 in bladder cancer [ 1 ]

Location

 TSS1500 (cg22937444)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.07E+00 Statistic Test p-value:7.85E-03; Z-score:-1.58E+00

Methylation in Case

 6.47E-01 (Median) Methylation in Control 6.94E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Breast cancer

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of KCNJ11 in breast cancer [ 2 ]

Location

 TSS1500 (cg22937444)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:2.49E-05; Z-score:-8.01E-01

Methylation in Case

 7.20E-01 (Median) Methylation in Control 7.44E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of KCNJ11 in breast cancer [ 2 ]

Location

 TSS1500 (cg23065768)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.13E+00 Statistic Test p-value:9.20E-05; Z-score:-8.92E-01

Methylation in Case

 4.54E-01 (Median) Methylation in Control 5.11E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Colorectal cancer

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of KCNJ11 in colorectal cancer [ 3 ]

Location

 TSS1500 (cg22937444)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:5.56E-04; Z-score:-8.32E-01

Methylation in Case

 8.37E-01 (Median) Methylation in Control 8.63E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Lung adenocarcinoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of KCNJ11 in lung adenocarcinoma [ 4 ]

Location

 TSS1500 (cg22937444)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.04E+00 Statistic Test p-value:2.09E-02; Z-score:1.01E+00

Methylation in Case

 7.96E-01 (Median) Methylation in Control 7.68E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Papillary thyroid cancer

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of KCNJ11 in papillary thyroid cancer [ 5 ]

Location

 TSS1500 (cg22937444)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.02E+00 Statistic Test p-value:2.72E-02; Z-score:6.04E-01

Methylation in Case

 8.70E-01 (Median) Methylation in Control 8.50E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Pancretic ductal adenocarcinoma

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of KCNJ11 in pancretic ductal adenocarcinoma [ 6 ]

Location

 TSS200 (cg21694044)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.32E+00 Statistic Test p-value:3.00E-08; Z-score:-1.43E+00

Methylation in Case

 1.78E-01 (Median) Methylation in Control 2.36E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of KCNJ11 in pancretic ductal adenocarcinoma [ 6 ]

Location

 Body (cg12146829)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.86E+00 Statistic Test p-value:6.56E-07; Z-score:-1.38E+00

Methylation in Case

 2.61E-01 (Median) Methylation in Control 4.86E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Hepatocellular carcinoma

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of KCNJ11 in hepatocellular carcinoma [ 7 ]

Location

 Body (cg20102878)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.33E+00 Statistic Test p-value:8.41E-13; Z-score:-4.08E+00

Methylation in Case

 6.32E-01 (Median) Methylation in Control 8.42E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples
References
1 DNA Methylation Dynamics in Urological Tumors.
2 Genome-wide Scan for Methylation Profiles in Breast Cancer
3 Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
4 DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues
5 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
6 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
7 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.

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