Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0511 Transporter Info
Gene Name	KCNJ11
Transporter Name	ATP-sensitive inward rectifier potassium channel 11
Gene ID	3767
UniProt ID	Q14654

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[1]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[2]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[3]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[4]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
mutated HNF4A (rs1884613)		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene in type 2 diabetes condition			[5]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	Type 2 diabetes [ICD11: 5A11]
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Experimental Material	human Type 2 diabetes blood isolates
Detailed Description	mutated Hepatocyte nuclear factor 4-alpha (mutated HNF4A (rs1884613)) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
mutated HNF4A (rs2144908)		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene in type 2 diabetes condition			[5]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	Type 2 diabetes [ICD11: 5A11]
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Experimental Material	human Type 2 diabetes blood isolates
Detailed Description	mutated Hepatocyte nuclear factor 4-alpha (mutated HNF4A (rs2144908)) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
mutated HNF4A (rs4810424)		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene in type 2 diabetes condition			[5]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	Type 2 diabetes [ICD11: 5A11]
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Experimental Material	human Type 2 diabetes blood isolates
Detailed Description	mutated Hepatocyte nuclear factor 4-alpha (mutated HNF4A (rs4810424)) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[2]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of KCNJ11 gene in breast cancer condition			[6]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Affected Drug/Substrate	ST247 and DG172
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of KCNJ11 gene in breast cancer condition, which leads to a decreased expression of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
RARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[4]
TF Protein Name	Retinoic acid receptor gamma		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor gamma (RARG) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[1]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[4]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNJ11 gene in erythroleukemia condition			[7]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of KCNJ11 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[2]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Foreskin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[1]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[3]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[3]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[4]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
ISL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of KCNJ11 gene in health condition			[8]
TF Protein Name	Insulin gene enhancer protein ISL-1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Small intestine
Related DT Changes	Up regulating
Experimental Material	Rat small intestine epithelial cells (IEC-6)
Detailed Description	Insulin gene enhancer protein ISL-1 (ISL1) has been reported to activate the transcription of KCNJ11 gene in health condition, which leads to an increased expression of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
PDX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of KCNJ11 gene in health condition			[9]
TF Protein Name	Pancreas/duodenum homeobox protein 1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Embryo
Related DT Changes	Up regulating
Experimental Material	Mouse embryo embryonic stem cells (EB3)
Detailed Description	Pancreas/duodenum homeobox protein 1 (PDX1) has been reported to activate the transcription of KCNJ11 gene in health condition, which leads to an increased expression of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of KCNJ11 gene in health condition			[10]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to activate the transcription of KCNJ11 gene in health condition, which leads to an increased expression of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
Transcriptional Phenomenon2	Direct binding to KCNJ11 gene			[1]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Blood; Breast; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[2]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
FOXA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNJ11 gene in prostate carcinoma condition			[11]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of KCNJ11 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
Transcriptional Phenomenon2	Direct binding to KCNJ11 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Lung; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNJ11 gene			[12]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of KCNJ11 gene in . condition, which leads to a affected expression of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[4]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[1]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Bone marrow; Liver; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[2]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
TF Superclass6: Immunoglobulin fold
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNJ11 gene in HFKS condition			[13]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of KCNJ11 gene in HFKS condition, which leads to an affected expression of the drug transporter ATP-sensitive inward rectifier potassium channel 11.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNJ11 gene			[3]
TF Protein Name	Grainyhead-like protein 3 homolog		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the KCNJ11 gene, which in turn affects the expression or function of the drug transporter ATP-sensitive inward rectifier potassium channel 11.

References
1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-433. (ID:ENSG00000187486)
5	Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women. Diabet Med. 2007 Nov;24(11):1187-91.
6	Inverse PPAR agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion. Oncogene. 2013;32(44):5241-52.
7	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
8	Regulation of ATP-sensitive potassium channel subunit Kir6.2 expression in rat intestinal insulin-producing progenitor cells. J Biol Chem. 2005 Jan 21;280(3):1893-900.
9	Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes. 2004 Apr;53(4):1030-7.
10	The CDK4-pRB-E2F1 pathway controls insulin secretion. Nat Cell Biol. 2009 Aug;11(8):1017-23.
11	SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
12	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
13	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.

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Detail Information of Transcriptional Regulations

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