Drug Transporter (DT) Information

General Information of DT
DT ID DTD0488
Gene Name SLC9A4
Protein Name Sodium/hydrogen exchanger 4
Gene ID
389015
UniProt ID
Q6AI14
TCDB ID
2.A.36.1.18
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms NHE-4; NHE4; Na(+)/H(+) exchanger 4; SLC9A4; Solute carrier family 9 member 4
DT Family Monovalent Cation:Proton Antiporter-1 (CPA1) family ;
Function This transporter mediates and participates in regulating pH value to eliminate acids generated by active metabolism or to combat adverse environmental conditions. May play a special role in kidney, regulating cell volume to cope with extreme fluctuations of hypertonic stimulation cell contraction.
Endogenous Substrate(s) Na+; H+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/hydrogen exchanger 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/hydrogen exchanger 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/hydrogen exchanger 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium/hydrogen exchanger 4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/hydrogen exchanger 4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/hydrogen exchanger 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/hydrogen exchanger 4
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/hydrogen exchanger 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/hydrogen exchanger 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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