Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0488 Transporter Info
Gene Name SLC9A4
Transporter Name Sodium/hydrogen exchanger 4
Gene ID
389015
UniProt ID
Q6AI14

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A4 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone marrow; Breast; Cervix; Colon; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC9A4 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 4.

      Class1.2: Basic helix-loop-helix factors

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        MYC 

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       Transcriptional Phenomenon1

 Binding to SLC9A4 gene in embryonic stem cells condition [2]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC9A4 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 4.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        NR3C1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A4 gene in ER(-) breast cancer condition [3]

TF Protein Name

 Glucocorticoid receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC9A4 gene in ER(-) breast cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 4.

      Class2.3: C2H2 zinc finger factors

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        KLF5 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A4 gene in gastric cancer condition [4]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC9A4 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 4.

       Transcriptional Phenomenon2

 Direct binding to SLC9A4 gene [5]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC9A4 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 4.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A4 gene in podocyte condition [6]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC9A4 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 4.

        ZNF217 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A4 gene in breast cancer condition [7]

TF Protein Name

 Zinc finger protein 217 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC9A4 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 4.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXM1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A4 gene in breast cancer condition [8]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC9A4 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 4.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A4 gene in epithelial ovarian cancer condition [9]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC9A4 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 4.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-413. (ID:ENSG00000180251)
2 Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
3 Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 2011;71(20):6360-70.
4 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
5 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
6 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
7 Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
8 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
9 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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