Drug Transporter (DT) Information

General Information of DT
DT ID DTD0422
Gene Name SLC5A2
Protein Name Sodium/glucose cotransporter 2
Gene ID
6524
UniProt ID
P31639
TCDB ID
2.A.21.3.16
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:2XQ2_A

Identity:32.842%

Minimized Score:-979.24 kcal/mol

Detail: Structure Info

Synonyms Low affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 2; SGLT2; SLC5A2; Solute carrier family 5 member 2
DT Family Solute:Sodium Symporter (SSS) Family ;
Function This sodium-dependent transporter mediate the transport of glucose.
Endogenous Substrate(s) D-glucose
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/glucose cotransporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/glucose cotransporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/glucose cotransporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium/glucose cotransporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/glucose cotransporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/glucose cotransporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/glucose cotransporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/glucose cotransporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/glucose cotransporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
D-glucose
 Approved Drug Info Hypoglycemia 5A21; 5A41 [1]
References
1 The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977.

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