General Information of Drug Transporter (DT)
DT ID	DTD0422 Transporter Info
Gene Name	SLC5A2
Protein Name	Sodium/glucose cotransporter 2
Gene ID	6524
UniProt ID	P31639
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs11646054
Site of GPD	chr16:31484350 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A / G>C / G>T
Minor Allele Frequency	G=0.6990/1383 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Empagliflozin	N.A.	Alcohol Abuse	Allele C is not associated with response to empagliflozin in people with Diabetes Mellitus, Type 2 as compared to allele G.		[ 1]
Genetic Polymorphism	rs3116149
Site of GPD	chr16:31484405 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	G=0.8990/1779 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Empagliflozin	N.A.	Alcohol Abuse	Allele A is not associated with response to empagliflozin in people with Diabetes Mellitus, Type 2 as compared to allele G.		[ 1]
Genetic Polymorphism	rs3116150
Site of GPD	chr16:31486700 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	G=0.9020/1785 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Empagliflozin	N.A.	Alcohol Abuse	Allele A is not associated with response to empagliflozin in people with Diabetes Mellitus, Type 2 as compared to allele G.		[ 1]
Genetic Polymorphism	rs9924771
Site of GPD	chr16:31484256 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G / A>T
Minor Allele Frequency	A=0.3340/660 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Empagliflozin	N.A.	Alcohol Abuse	Allele A is not associated with response to empagliflozin in people with Diabetes Mellitus, Type 2 as compared to allele G.		[ 1]
Genetic Polymorphism	rs3813008
Site of GPD	chr16:31486560 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A / G>C
Minor Allele Frequency	G=0.8210/1624 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Empagliflozin	N.A.	Alcohol Abuse	Allele A is not associated with response to empagliflozin in people with Diabetes Mellitus, Type 2 as compared to allele G.		[ 1]
References
1	Influence of common polymorphisms in the SLC5A2 gene on metabolic traits in subjects at increased risk of diabetes and on response to empagliflozin treatment in patients with diabetes. Pharmacogenet Genomics. 2017 Apr;27(4):135-142.

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