Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0422 Transporter Info
Gene Name SLC5A2
Transporter Name Sodium/glucose cotransporter 2
Gene ID
6524
UniProt ID
P31639

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        NFE2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [2]

TF Protein Name

 Transcription factor NF-E2 45 kDa subunit Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        NFE2L2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A2 gene in diabetes mellitus condition [3]

TF Protein Name

 Nuclear factor erythroid 2-related factor 2 Transcription Factor Info

Studied Phenotype

 Diabetes mellitus [ICD11: 5A10-5A14]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 diabetic Akita Nrf2 KO/Nrf2RPTC transgenic mice

Detailed Description

 Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of SLC5A2 gene in diabetes mellitus condition, which leads to an increased expression of the drug transporter Sodium/glucose cotransporter 2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        BHLHE40 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [4]

TF Protein Name

 Class E basic helix-loop-helix protein 40 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        MYC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A2 gene in embryonic stem cells condition [5]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC5A2 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Sodium/glucose cotransporter 2.

        TAL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [6]

TF Protein Name

 T-cell acute lymphocytic leukemia protein 1 Transcription Factor Info

Tissue

 Bone marrow; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 T-cell acute lymphocytic leukemia protein 1 (TAL1) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [1]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        TFAP4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [4]

TF Protein Name

 Transcription factor AP-4 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-4 (TFAP4) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        HNF4A 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC5A2 gene in health condition [7]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC5A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium/glucose cotransporter 2.

       Transcriptional Phenomenon2

 Activation of SLC5A2 gene in type 2 diabetes condition [8]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 Type 2 diabetes [ICD11: 5A11]

Tissue

 Pancreas

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to activate the transcription of SLC5A2 gene in type 2 diabetes condition, which leads to an increased expression of the drug transporter Sodium/glucose cotransporter 2.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [4]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [1]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [4]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 9 TF(s) Regulating This DT

        BCL6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [2]

TF Protein Name

 B-cell lymphoma 6 protein Transcription Factor Info

Tissue

 Tonsil

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [6]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        CTCFL 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [6]

TF Protein Name

 Transcriptional repressor CTCFL Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [2]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 1 (KLF1) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [6]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [1]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [4]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Bone marrow; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [2]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        HNF1B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A2 gene in renal cysts condition [9]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to activate the transcription of SLC5A2 gene in renal cysts condition, which leads to an increased expression of the drug transporter Sodium/glucose cotransporter 2.

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A2 gene in ovarian cancer condition [10]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC5A2 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Sodium/glucose cotransporter 2.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [2]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Bone marrow; Embryo; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [4]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Endoderm; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [6]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [1]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [6]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [2]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

TF Superclass5: alpha-Helices exposed by beta-structures

      Class5.1: MADS box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SRF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [6]

TF Protein Name

 Serum response factor Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Serum response factor (SRF) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [4]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.

        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC5A2 gene in fibrosarcoma condition [11]

TF Protein Name

 Transcription factor p65 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor p65 (RELA) has been reported to activate the transcription of SLC5A2 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Sodium/glucose cotransporter 2.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.5: GTF2I domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GTF2I 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC5A2 gene [2]

TF Protein Name

 General transcription factor II-I Transcription Factor Info

Tissue

 Foreskin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 General transcription factor II-I (GTF2I) can directly bind to the SLC5A2 gene, which in turn affects the expression or function of the drug transporter Sodium/glucose cotransporter 2.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3 Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium-Glucose Cotransporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice. Diabetes. 2021 Jun;70(6):1388-1403.
4 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5 Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
6 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-296. (ID:ENSG00000140675)
7 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
8 Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat Med. 2015 May;21(5):512-7.
9 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
10 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
11 Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.

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