Drug Transporter (DT) Information

General Information of DT
DT ID DTD0388
Gene Name SLC4A8
Protein Name Electroneutral sodium bicarbonate exchanger 1
Gene ID
9498
UniProt ID
Q2Y0W8
TCDB ID
2.A.31.2.4
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6CAA_A

Identity:56.484%

Minimized Score:-1548.413 kcal/mol

Detail: Structure Info

Synonyms Electroneutral Na(+)-driven Cl-HCO3 exchanger; KIAA0739; NDCBE; NDCBE1; SLC4A8; Solute carrier family 4 member 8; k-NBC3
DT Family Anion Exchanger (AE) Family ;
Function This transporter regulates pH in neurons and mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
Endogenous Substrate(s) Cl-; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Electroneutral sodium bicarbonate exchanger 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Electroneutral sodium bicarbonate exchanger 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Electroneutral sodium bicarbonate exchanger 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Electroneutral sodium bicarbonate exchanger 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Electroneutral sodium bicarbonate exchanger 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Electroneutral sodium bicarbonate exchanger 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Electroneutral sodium bicarbonate exchanger 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Electroneutral sodium bicarbonate exchanger 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Electroneutral sodium bicarbonate exchanger 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sodium bicarbonate
 Approved Drug Info Metabolic acidosis 5C73 [1]
References
1 The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60.

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