General Information of Drug Transporter (DT)
DT ID	DTD0388 Transporter Info
Gene Name	SLC4A8
Protein Name	Electroneutral sodium bicarbonate exchanger 1
Gene ID	9498
UniProt ID	Q2Y0W8
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs12296477
Site of GPD	chr12:51510076 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>G
Minor Allele Frequency	C=0.6840/1353 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ethanol	N.A.	Alcohol Abuse	Allele C is associated with increased risk of Alcoholism due to ethanol as compared to allele G.		[ 1]
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ethanol	N.A.	Alcohol Abuse	Patients with the CC genotype may be at an increased risk of developing alcoholism as compared to patients with the GG genotype. Other genetic and clinical factors may also affect a patient's risk of developing alcoholism.		[ 1]
Genotype CG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ethanol	N.A.	Alcohol Abuse	Patients with the CG genotype may be at an increased risk of developing alcoholism as compared to patients with the GG genotype. Other genetic and clinical factors may also affect a patient's risk of developing alcoholism.		[ 1]
Genotype GG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Ethanol	N.A.	Alcohol Abuse	Patients with the GG genotype may be at a decreased risk of developing alcoholism as compared to patients with the CC or CG genotypes. Other genetic and clinical factors may also affect a patient's risk of developing alcoholism.		[ 1]
References
1	Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. Nat Neurosci. 2020 Jul;23(7):809-818.

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