Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00038
|
|||||
| Drug Name |
Sodium bicarbonate
|
|||||
| Synonyms |
800 Sodium Bicarbonate Powder; Acidosan; BSS plus; Baking soda; Bicarbonate of soda; Bicarbonate, Sodium; Carbonic acid monosodium salt; Carbonic acid sodium salt (1:1); Carbonic acid, monosodium salt; Co-lav; Col-evac; Colovage; E-Z-EM Prep Lyte; Glycoprep; Go-evac; Golytely; Gripe water; Hema BP-38; Hydrogen Carbonate, Sodium; Jusonin; Lithium bicarbonate; Meylon; Meylon (TN); Monosodium carbonate; Monosodium hydrogen carbonate; NaHCO3; Natrii hydrogencarbonas; Natrium bicarbonicum; Natrium hydrogencarbonicum; Natriumhydrogenkarbonat; Natron; Natrum bicarbonicum; Neut; Neut (TN); Nulytely; Peg-lyte; Sandoz sodium bicarbonate; Sel De vichy; Soda (van); Soda Mint; Soda, Baking; Sodium acid carbonate; Sodium bicarbonate (1:1); Sodium bicarbonate (JP15/USP); Sodium bicarbonate [USAN:JAN]; Sodium bicarbonate in plastic container; Sodium bicarbonate liquid concentrate; Sodium bicarbonate solution; Sodium carbonate (Na(HCO3)); Sodium hydrocarbonate; Sodium hydrogen carbonate; Sodium hydrogencarbonate; Soludal
|
|||||
| Drug Type |
Small molecular drug
|
|||||
| Indication | Metabolic acidosis [ICD11:5C73] | Approved | [1] | |||
| Therapeutic Class |
Antidiarrheals
|
|||||
| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
CHNaO3
|
|||||
| Canonical SMILES |
C(=O)(O)[O-].[Na+]
|
|||||
| InChI |
InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
|
|||||
| InChIKey |
UIIMBOGNXHQVGW-UHFFFAOYSA-M
|
|||||
| CAS Number |
CAS 144-55-8
|
|||||
| Pharmaceutical Properties | Molecular Weight | 84.007 | Topological Polar Surface Area | 60.4 | ||
| Heavy Atom Count | 5 | Rotatable Bond Count | 0 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 3 | |||
| PubChem CID | ||||||
| PubChem SID |
103446806
,104042946
,10500654
,10501487
,109756634
,11528438
,117376339
,124391975
,125307120
,125311860
,134337450
,134974257
,135091883
,135551762
,137001566
,140077586
,142262832
,143489532
,151975740
,15296910
,24848145
,24858955
,24862462
,24865036
,24889074
,24899571
,24899582
,24899673
,24899682
,24899695
,24899739
,24899815
,24899817
,29227583
,3133633
,46507049
,48414455
,48420011
,4977523
,50755492
,50755494
,53787141
,57405912
,57647084
,57648561
,57654616
,582993
,7848266
,8147837
,8669758
|
|||||
| ChEBI ID |
ChEBI:32139
|
|||||
| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | AE4 | Transporter Info | Anion exchange protein 4 | Substrate | [2] | |
| NBC3 | Transporter Info | Sodium bicarbonate cotransporter 3 | Substrate | [3] | ||
| NBCe1 | Transporter Info | Electrogenic sodium bicarbonate cotransporter 1 | Substrate | [4] | ||
| NBCe2 | Transporter Info | Electrogenic sodium bicarbonate cotransporter 4 | Substrate | [3] | ||
| NCBE | Transporter Info | Sodium-driven chloride bicarbonate exchanger | Substrate | [5] | ||
| NDCBE | Transporter Info | Electroneutral sodium bicarbonate exchanger 1 | Substrate | [3] | ||
| References | ||||||
| 1 | The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106. (familyId=4507) | |||||
| 2 | A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. Genome Biol. 2001;2(4):RESEARCH0011. | |||||
| 3 | The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. | |||||
| 4 | The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem. 2010 Aug 6;285(32):24432-8. | |||||
| 5 | Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.