Drug Transporter (DT) Information

General Information of DT
DT ID DTD0386
Gene Name SLC4A5
Protein Name Electrogenic sodium bicarbonate cotransporter 4
Gene ID
57835
UniProt ID
Q9BY07
TCDB ID
2.A.31.2.8
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6CAA_A

Identity:64.438%

Minimized Score:-1008.921 kcal/mol

Detail: Structure Info

Synonyms NBC4; NBCe2; SLC4A5; Solute carrier family 4 member 5
DT Family Anion Exchanger (AE) Family ;
Function This transporter regulates the pH of tissues and may play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. Also may be important in protecting the renal paranchyma from alterations in urine pH.
Endogenous Substrate(s) Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Electrogenic sodium bicarbonate cotransporter 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Electrogenic sodium bicarbonate cotransporter 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Electrogenic sodium bicarbonate cotransporter 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Electrogenic sodium bicarbonate cotransporter 4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Electrogenic sodium bicarbonate cotransporter 4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Electrogenic sodium bicarbonate cotransporter 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Electrogenic sodium bicarbonate cotransporter 4
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Electrogenic sodium bicarbonate cotransporter 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Electrogenic sodium bicarbonate cotransporter 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sodium bicarbonate
 Approved Drug Info Metabolic acidosis 5C73 [1]
References
1 The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60.

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