Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID DTD0386 Transporter Info
Gene Name SLC4A5
Transporter Name Electrogenic sodium bicarbonate cotransporter 4
Gene ID
57835
UniProt ID
Q9BY07
Epigenetic Regulations of This DT (EGR)

Methylation

  Atypical teratoid rhabdoid tumor

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in atypical teratoid rhabdoid tumor [ 1 ]

Location

 5'UTR (cg00945862)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.09E+00 Statistic Test p-value:6.85E-09; Z-score:2.01E+00

Methylation in Case

 4.44E-01 (Median) Methylation in Control 2.12E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in atypical teratoid rhabdoid tumor [ 1 ]

Location

 5'UTR (cg14932645)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.08E+00 Statistic Test p-value:9.84E-07; Z-score:1.36E+00

Methylation in Case

 9.02E-01 (Median) Methylation in Control 8.32E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC4A5 in atypical teratoid rhabdoid tumor [ 1 ]

Location

 3'UTR (ch.2.1685478R)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:3.65E-09; Z-score:-1.44E+00

Methylation in Case

 8.67E-01 (Median) Methylation in Control 9.21E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Bladder cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in bladder cancer [ 2 ]

Location

 5'UTR (cg14932645)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.04E+00 Statistic Test p-value:2.33E-04; Z-score:-3.99E+00

Methylation in Case

 8.69E-01 (Median) Methylation in Control 9.04E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in bladder cancer [ 2 ]

Location

 TSS1500 (cg13459852)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.10E+00 Statistic Test p-value:1.13E-02; Z-score:2.42E+00

Methylation in Case

 7.64E-01 (Median) Methylation in Control 6.95E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC4A5 in bladder cancer [ 2 ]

Location

 TSS200 (cg25811526)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.44E+00 Statistic Test p-value:6.42E-06; Z-score:-7.10E+00

Methylation in Case

 3.53E-01 (Median) Methylation in Control 5.09E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Breast cancer

            7 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in breast cancer [ 3 ]

Location

 5'UTR (cg14932645)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:2.54E-06; Z-score:-1.20E+00

Methylation in Case

 8.68E-01 (Median) Methylation in Control 8.97E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in breast cancer [ 3 ]

Location

 5'UTR (cg00945862)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.09E+00 Statistic Test p-value:1.16E-02; Z-score:-9.85E-01

Methylation in Case

 7.94E-01 (Median) Methylation in Control 8.67E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC4A5 in breast cancer [ 3 ]

Location

 TSS1500 (cg17808746)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.07E+00 Statistic Test p-value:1.99E-02; Z-score:-8.57E-01

Methylation in Case

 7.60E-01 (Median) Methylation in Control 8.15E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC4A5 in breast cancer [ 3 ]

Location

 TSS1500 (cg15845653)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.00E+00 Statistic Test p-value:4.85E-02; Z-score:-1.37E-01

Methylation in Case

 8.65E-01 (Median) Methylation in Control 8.67E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of SLC4A5 in breast cancer [ 3 ]

Location

 TSS200 (cg25811526)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.13E+00 Statistic Test p-value:1.02E-03; Z-score:-9.49E-01

Methylation in Case

 4.84E-01 (Median) Methylation in Control 5.46E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of SLC4A5 in breast cancer [ 3 ]

Location

 TSS200 (cg26319800)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.05E+00 Statistic Test p-value:1.32E-02; Z-score:-6.34E-01

Methylation in Case

 8.29E-01 (Median) Methylation in Control 8.74E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon7

 Methylation of SLC4A5 in breast cancer [ 3 ]

Location

 3'UTR (ch.2.1685478R)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.37E+00 Statistic Test p-value:1.30E-02; Z-score:-6.60E-01

Methylation in Case

 2.56E-02 (Median) Methylation in Control 3.51E-02 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Colorectal cancer

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in colorectal cancer [ 4 ]

Location

 5'UTR (cg00945862)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.02E+00 Statistic Test p-value:2.55E-05; Z-score:-1.80E+00

Methylation in Case

 9.16E-01 (Median) Methylation in Control 9.30E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in colorectal cancer [ 4 ]

Location

 5'UTR (cg14932645)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.00E+00 Statistic Test p-value:3.24E-03; Z-score:-6.59E-02

Methylation in Case

 9.36E-01 (Median) Methylation in Control 9.37E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC4A5 in colorectal cancer [ 4 ]

Location

 TSS200 (cg25811526)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.36E+00 Statistic Test p-value:1.18E-12; Z-score:-3.07E+00

Methylation in Case

 5.05E-01 (Median) Methylation in Control 6.86E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Hepatocellular carcinoma

            7 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in hepatocellular carcinoma [ 5 ]

Location

 5'UTR (cg00945862)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.04E+00 Statistic Test p-value:9.24E-06; Z-score:-1.29E+00

Methylation in Case

 8.12E-01 (Median) Methylation in Control 8.44E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in hepatocellular carcinoma [ 5 ]

Location

 TSS1500 (cg15845653)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:1.67E-07; Z-score:-2.98E+00

Methylation in Case

 8.15E-01 (Median) Methylation in Control 8.65E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC4A5 in hepatocellular carcinoma [ 5 ]

Location

 TSS1500 (cg13459852)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:1.07E-05; Z-score:-1.39E+00

Methylation in Case

 7.34E-01 (Median) Methylation in Control 7.80E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC4A5 in hepatocellular carcinoma [ 5 ]

Location

 TSS1500 (cg17808746)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:4.21E-02; Z-score:-1.69E-01

Methylation in Case

 7.88E-01 (Median) Methylation in Control 7.95E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of SLC4A5 in hepatocellular carcinoma [ 5 ]

Location

 TSS200 (cg26319800)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.04E+00 Statistic Test p-value:4.01E-05; Z-score:-1.10E+00

Methylation in Case

 8.30E-01 (Median) Methylation in Control 8.66E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of SLC4A5 in hepatocellular carcinoma [ 5 ]

Location

 3'UTR (cg19237530)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.33E+00 Statistic Test p-value:2.49E-13; Z-score:-8.02E+00

Methylation in Case

 6.43E-01 (Median) Methylation in Control 8.58E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon7

 Methylation of SLC4A5 in hepatocellular carcinoma [ 5 ]

Location

 3'UTR (ch.2.1685478R)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.23E+00 Statistic Test p-value:1.28E-03; Z-score:-5.45E-01

Methylation in Case

 5.14E-02 (Median) Methylation in Control 6.30E-02 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  HIV infection

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in HIV infection [ 6 ]

Location

 5'UTR (cg00945862)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.02E+00 Statistic Test p-value:3.38E-03; Z-score:-9.33E-01

Methylation in Case

 8.90E-01 (Median) Methylation in Control 9.07E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in HIV infection [ 6 ]

Location

 TSS1500 (cg13459852)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.05E+00 Statistic Test p-value:1.06E-04; Z-score:1.10E+00

Methylation in Case

 8.32E-01 (Median) Methylation in Control 7.94E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC4A5 in HIV infection [ 6 ]

Location

 TSS1500 (cg17808746)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:5.27E-04; Z-score:-9.79E-01

Methylation in Case

 8.39E-01 (Median) Methylation in Control 8.64E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC4A5 in HIV infection [ 6 ]

Location

 TSS200 (cg25811526)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.17E+00 Statistic Test p-value:7.43E-06; Z-score:-2.22E+00

Methylation in Case

 5.80E-01 (Median) Methylation in Control 6.77E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Panic disorder

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in panic disorder [ 7 ]

Location

 5'UTR (cg00945862)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.03E+00 Statistic Test p-value:2.40E-03; Z-score:2.95E-01

Methylation in Case

 3.32E+00 (Median) Methylation in Control 3.22E+00 (Median)

Studied Phenotype

 Panic disorder[ ICD-11:6B01]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in panic disorder [ 7 ]

Location

 TSS200 (cg25811526)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.16E+00 Statistic Test p-value:2.43E-02; Z-score:3.90E-01

Methylation in Case

 1.49E+00 (Median) Methylation in Control 1.29E+00 (Median)

Studied Phenotype

 Panic disorder[ ICD-11:6B01]

Experimental Material

 Patient tissue samples

  Papillary thyroid cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in papillary thyroid cancer [ 8 ]

Location

 5'UTR (cg14932645)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:6.10E-03; Z-score:-4.55E-01

Methylation in Case

 9.27E-01 (Median) Methylation in Control 9.34E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in papillary thyroid cancer [ 8 ]

Location

 TSS1500 (cg15845653)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.06E+00 Statistic Test p-value:1.73E-04; Z-score:9.51E-01

Methylation in Case

 8.24E-01 (Median) Methylation in Control 7.79E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC4A5 in papillary thyroid cancer [ 8 ]

Location

 TSS1500 (cg13459852)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.08E+00 Statistic Test p-value:5.78E-04; Z-score:1.18E+00

Methylation in Case

 7.62E-01 (Median) Methylation in Control 7.07E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Pancretic ductal adenocarcinoma

            8 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in pancretic ductal adenocarcinoma [ 9 ]

Location

 TSS1500 (cg07337598)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.09E+00 Statistic Test p-value:3.07E-03; Z-score:-8.70E-01

Methylation in Case

 6.20E-01 (Median) Methylation in Control 6.77E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in pancretic ductal adenocarcinoma [ 9 ]

Location

 TSS200 (cg06237487)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:6.23E-03; Z-score:-4.57E-01

Methylation in Case

 8.33E-01 (Median) Methylation in Control 8.57E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC4A5 in pancretic ductal adenocarcinoma [ 9 ]

Location

 TSS200 (cg18420266)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.09E+00 Statistic Test p-value:2.42E-02; Z-score:-6.06E-01

Methylation in Case

 9.01E-02 (Median) Methylation in Control 9.79E-02 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC4A5 in pancretic ductal adenocarcinoma [ 9 ]

Location

 Body (cg03816707)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.61E+00 Statistic Test p-value:7.51E-12; Z-score:2.09E+00

Methylation in Case

 5.06E-01 (Median) Methylation in Control 3.15E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of SLC4A5 in pancretic ductal adenocarcinoma [ 9 ]

Location

 Body (cg16087826)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.30E+00 Statistic Test p-value:6.41E-05; Z-score:-1.43E+00

Methylation in Case

 6.29E-01 (Median) Methylation in Control 8.20E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of SLC4A5 in pancretic ductal adenocarcinoma [ 9 ]

Location

 Body (cg14708080)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.05E+00 Statistic Test p-value:2.56E-03; Z-score:1.57E-01

Methylation in Case

 5.19E-02 (Median) Methylation in Control 4.96E-02 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon7

 Methylation of SLC4A5 in pancretic ductal adenocarcinoma [ 9 ]

Location

 Body (cg19664229)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.15E+00 Statistic Test p-value:3.04E-03; Z-score:9.45E-01

Methylation in Case

 5.83E-01 (Median) Methylation in Control 5.08E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon8

 Methylation of SLC4A5 in pancretic ductal adenocarcinoma [ 9 ]

Location

 Body (cg13473691)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.05E+00 Statistic Test p-value:4.66E-02; Z-score:4.89E-01

Methylation in Case

 5.25E-01 (Median) Methylation in Control 5.00E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Systemic lupus erythematosus

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in systemic lupus erythematosus [ 10 ]

Location

 TSS1500 (cg17808746)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.00E+00 Statistic Test p-value:3.33E-02; Z-score:-7.90E-02

Methylation in Case

 8.52E-01 (Median) Methylation in Control 8.54E-01 (Median)

Studied Phenotype

 Systemic lupus erythematosus[ ICD-11:4A40.0]

Experimental Material

 Patient tissue samples

  Lung adenocarcinoma

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC4A5 in lung adenocarcinoma [ 11 ]

Location

 TSS200 (cg25811526)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.13E+00 Statistic Test p-value:9.53E-04; Z-score:-3.08E+00

Methylation in Case

 5.56E-01 (Median) Methylation in Control 6.29E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC4A5 in lung adenocarcinoma [ 11 ]

Location

 TSS200 (cg26319800)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:1.82E-02; Z-score:-1.85E+00

Methylation in Case

 8.73E-01 (Median) Methylation in Control 8.98E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples
References
1 Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell. 2016 Mar 14;29(3):379-393.
2 DNA Methylation Dynamics in Urological Tumors.
3 Genome-wide Scan for Methylation Profiles in Breast Cancer
4 Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
5 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
6 HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis. 2015 Nov 15;212(10):1563-73.
7 DNA Methylation signatures in panic disorder. Transl Psychiatry. 2017 Dec 18;7(12):1287.
8 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
9 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
10 Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet. 2013;9(8):e1003678.
11 DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues

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