Drug Transporter (DT) Information

General Information of DT
DT ID DTD0385
Gene Name SLC4A4
Protein Name Electrogenic sodium bicarbonate cotransporter 1
Gene ID
8671
UniProt ID
Q9Y6R1
TCDB ID
2.A.31.2.12
3D Structure

Modelled DT Structure

Method:loop building

Template PDB:6CAA_A

Identity:99.5%

Minimized Score:-1090.347 kcal/mol

Detail: Structure Info

Synonyms HNBC1; KNBC; NBC1; NBCE1; NBCe1-A; Na(+)/HCO3(-) cotransporter; SLC4A4; Sodium bicarbonate cotransporter; Solute carrier family 4 member 4; hhNMC; kNBC1; pNBC
DT Family Anion Exchanger (AE) Family ;
Tissue Specificity Isoform 1 is expressed in pancreas and to alower extent in heart, skeletal muscle, liver, parotid salivaryglands, prostate, colon, stomach, thyroid, brain and spinal chord.Corneal endothelium cells express only isoform 1 (at proteinlevel). Isoform 2 is specifically expressed in kidney at the levelof proximal tubules.
Function This transporter may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3.
Endogenous Substrate(s) Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Electrogenic sodium bicarbonate cotransporter 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Electrogenic sodium bicarbonate cotransporter 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Electrogenic sodium bicarbonate cotransporter 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Electrogenic sodium bicarbonate cotransporter 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Electrogenic sodium bicarbonate cotransporter 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Electrogenic sodium bicarbonate cotransporter 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Electrogenic sodium bicarbonate cotransporter 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Electrogenic sodium bicarbonate cotransporter 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Electrogenic sodium bicarbonate cotransporter 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sodium bicarbonate
 Approved Drug Info Metabolic acidosis 5C73 [1]
References
1 The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem. 2010 Aug 6;285(32):24432-8.

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