Drug Transporter (DT) Information

General Information of DT
DT ID DTD0389
Gene Name SLC4A9
Protein Name Anion exchange protein 4
Gene ID
83697
UniProt ID
Q96Q91
TCDB ID
2.A.31.2.13
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6CAA_A

Identity:52.396%

Minimized Score:-1603.086 kcal/mol

Detail: Structure Info

Synonyms AE 4; AE4; Anion exchanger 4; SBC5; SLC4A9; Sodium bicarbonate cotransporter 5; Solute carrier family 4 member 9
DT Family Anion Exchanger (AE) Family ;
Tissue Specificity Kidney specific.
Function This transporter is a probable apical anion exchanger of the kidney cortex.
Endogenous Substrate(s) Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Anion exchange protein 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Anion exchange protein 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Anion exchange protein 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Anion exchange protein 4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Anion exchange protein 4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Anion exchange protein 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Anion exchange protein 4
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Anion exchange protein 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Anion exchange protein 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sodium bicarbonate
 Approved Drug Info Metabolic acidosis 5C73 [1]
References
1 A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. Genome Biol. 2001;2(4):RESEARCH0011.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.