Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0389 Transporter Info
Gene Name	SLC4A9
Transporter Name	Anion exchange protein 4
Gene ID	83697
UniProt ID	Q96Q91

Epigenetic Regulations of This DT (EGR)
Methylation
Bladder cancer	6 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in bladder cancer			[ 1 ]
Location	TSS1500 (cg02481956)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-2.45E+00	Statistic Test	p-value:5.24E-13; Z-score:-1.28E+01
Methylation in Case	2.70E-01 (Median)	Methylation in Control	6.61E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in bladder cancer			[ 1 ]
Location	TSS200 (cg07493760)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.27E+00	Statistic Test	p-value:3.31E-06; Z-score:-4.65E+00
Methylation in Case	4.18E-01 (Median)	Methylation in Control	5.32E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in bladder cancer			[ 1 ]
Location	Body (cg08215811)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-2.16E+00	Statistic Test	p-value:6.80E-14; Z-score:-1.48E+01
Methylation in Case	8.96E-02 (Median)	Methylation in Control	1.94E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in bladder cancer			[ 1 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-2.40E+00	Statistic Test	p-value:4.73E-12; Z-score:-1.10E+01
Methylation in Case	2.44E-01 (Median)	Methylation in Control	5.86E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC4A9 in bladder cancer			[ 1 ]
Location	Body (cg06660015)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.96E+00	Statistic Test	p-value:6.57E-05; Z-score:-3.73E+00
Methylation in Case	1.55E-01 (Median)	Methylation in Control	3.05E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SLC4A9 in bladder cancer			[ 1 ]
Location	3'UTR (cg14564815)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.20E+00	Statistic Test	p-value:1.22E-04; Z-score:-4.79E+00
Methylation in Case	2.17E-01 (Median)	Methylation in Control	2.62E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Breast cancer	7 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in breast cancer			[ 2 ]
Location	TSS1500 (cg02481956)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.05E+00	Statistic Test	p-value:2.31E-04; Z-score:-1.06E+00
Methylation in Case	7.09E-01 (Median)	Methylation in Control	7.46E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in breast cancer			[ 2 ]
Location	TSS200 (cg07493760)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.03E+00	Statistic Test	p-value:1.30E-03; Z-score:-5.47E-01
Methylation in Case	6.02E-01 (Median)	Methylation in Control	6.20E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in breast cancer			[ 2 ]
Location	1stExon (cg08457872)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.08E+00	Statistic Test	p-value:2.28E-10; Z-score:-2.11E+00
Methylation in Case	7.24E-01 (Median)	Methylation in Control	7.85E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in breast cancer			[ 2 ]
Location	Body (cg08215811)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.54E+00	Statistic Test	p-value:9.33E-10; Z-score:-2.16E+00
Methylation in Case	1.33E-01 (Median)	Methylation in Control	2.05E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC4A9 in breast cancer			[ 2 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.67E+00	Statistic Test	p-value:1.76E-09; Z-score:-1.86E+00
Methylation in Case	3.33E-01 (Median)	Methylation in Control	5.58E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SLC4A9 in breast cancer			[ 2 ]
Location	Body (cg06660015)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.05E+00	Statistic Test	p-value:2.78E-02; Z-score:-2.15E-01
Methylation in Case	2.97E-01 (Median)	Methylation in Control	3.11E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SLC4A9 in breast cancer			[ 2 ]
Location	3'UTR (cg14564815)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.34E+00	Statistic Test	p-value:3.67E-08; Z-score:2.19E+00
Methylation in Case	2.79E-01 (Median)	Methylation in Control	2.08E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Colon cancer	3 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in colon adenocarcinoma			[ 3 ]
Location	TSS1500 (cg04344565)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.41E+00	Statistic Test	p-value:5.53E-08; Z-score:1.66E+00
Methylation in Case	5.18E-01 (Median)	Methylation in Control	3.69E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in colon adenocarcinoma			[ 3 ]
Location	TSS200 (cg15044957)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.25E+00	Statistic Test	p-value:5.85E-05; Z-score:1.04E+00
Methylation in Case	5.87E-01 (Median)	Methylation in Control	4.68E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in colon adenocarcinoma			[ 3 ]
Location	3'UTR (cg27024381)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.05E+00	Statistic Test	p-value:3.05E-03; Z-score:-1.20E+00
Methylation in Case	5.48E-01 (Median)	Methylation in Control	5.76E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Colorectal cancer	7 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in colorectal cancer			[ 4 ]
Location	TSS1500 (cg02481956)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.15E+00	Statistic Test	p-value:9.89E-06; Z-score:-1.44E+00
Methylation in Case	6.52E-01 (Median)	Methylation in Control	7.48E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in colorectal cancer			[ 4 ]
Location	TSS1500 (cg03551019)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.01E+00	Statistic Test	p-value:4.15E-02; Z-score:3.22E-01
Methylation in Case	9.23E-01 (Median)	Methylation in Control	9.12E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in colorectal cancer			[ 4 ]
Location	TSS200 (cg07493760)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.05E+00	Statistic Test	p-value:4.10E-03; Z-score:-6.69E-01
Methylation in Case	7.91E-01 (Median)	Methylation in Control	8.29E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in colorectal cancer			[ 4 ]
Location	1stExon (cg08457872)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.01E+00	Statistic Test	p-value:2.49E-04; Z-score:-1.04E+00
Methylation in Case	8.96E-01 (Median)	Methylation in Control	9.08E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC4A9 in colorectal cancer			[ 4 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.20E+00	Statistic Test	p-value:4.58E-07; Z-score:-1.54E+00
Methylation in Case	5.33E-01 (Median)	Methylation in Control	6.38E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SLC4A9 in colorectal cancer			[ 4 ]
Location	Body (cg18014856)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.08E+00	Statistic Test	p-value:3.43E-02; Z-score:5.28E-01
Methylation in Case	7.46E-02 (Median)	Methylation in Control	6.89E-02 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SLC4A9 in colorectal cancer			[ 4 ]
Location	3'UTR (cg14564815)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.06E+00	Statistic Test	p-value:1.03E-02; Z-score:5.44E-01
Methylation in Case	4.09E-01 (Median)	Methylation in Control	3.85E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Hepatocellular carcinoma	9 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in hepatocellular carcinoma			[ 5 ]
Location	TSS1500 (cg09638395)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.25E+00	Statistic Test	p-value:4.81E-10; Z-score:-3.97E+00
Methylation in Case	7.06E-01 (Median)	Methylation in Control	8.81E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in hepatocellular carcinoma			[ 5 ]
Location	TSS200 (cg06122660)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:2.33E+00	Statistic Test	p-value:9.56E-20; Z-score:5.21E+00
Methylation in Case	3.73E-01 (Median)	Methylation in Control	1.60E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in hepatocellular carcinoma			[ 5 ]
Location	TSS200 (cg07493760)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.02E+00	Statistic Test	p-value:3.37E-04; Z-score:-4.69E-01
Methylation in Case	6.81E-01 (Median)	Methylation in Control	6.96E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in hepatocellular carcinoma			[ 5 ]
Location	1stExon (cg13958974)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.60E+00	Statistic Test	p-value:1.58E-19; Z-score:4.96E+00
Methylation in Case	4.70E-01 (Median)	Methylation in Control	2.94E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC4A9 in hepatocellular carcinoma			[ 5 ]
Location	1stExon (cg08457872)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.03E+00	Statistic Test	p-value:4.56E-05; Z-score:-8.01E-01
Methylation in Case	7.81E-01 (Median)	Methylation in Control	8.01E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SLC4A9 in hepatocellular carcinoma			[ 5 ]
Location	Body (cg11234429)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.46E+00	Statistic Test	p-value:4.43E-17; Z-score:-4.71E+00
Methylation in Case	4.16E-01 (Median)	Methylation in Control	6.09E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SLC4A9 in hepatocellular carcinoma			[ 5 ]
Location	Body (cg08215811)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.19E+00	Statistic Test	p-value:8.15E-07; Z-score:-8.75E-01
Methylation in Case	8.92E-02 (Median)	Methylation in Control	1.06E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon8	Methylation of SLC4A9 in hepatocellular carcinoma			[ 5 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.26E+00	Statistic Test	p-value:1.69E-06; Z-score:-1.51E+00
Methylation in Case	3.72E-01 (Median)	Methylation in Control	4.71E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon9	Methylation of SLC4A9 in hepatocellular carcinoma			[ 5 ]
Location	Body (cg06660015)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.31E+00	Statistic Test	p-value:1.86E-02; Z-score:-9.21E-01
Methylation in Case	1.86E-01 (Median)	Methylation in Control	2.44E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
HIV infection	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in HIV infection			[ 6 ]
Location	TSS1500 (cg02481956)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.02E+00	Statistic Test	p-value:1.96E-03; Z-score:5.12E-01
Methylation in Case	7.98E-01 (Median)	Methylation in Control	7.84E-01 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in HIV infection			[ 6 ]
Location	1stExon (cg08457872)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.04E+00	Statistic Test	p-value:1.27E-03; Z-score:-1.21E+00
Methylation in Case	8.36E-01 (Median)	Methylation in Control	8.68E-01 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in HIV infection			[ 6 ]
Location	Body (cg06660015)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.20E+00	Statistic Test	p-value:1.95E-04; Z-score:1.10E+00
Methylation in Case	4.54E-01 (Median)	Methylation in Control	3.78E-01 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in HIV infection			[ 6 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.12E+00	Statistic Test	p-value:6.37E-04; Z-score:-9.05E-01
Methylation in Case	5.59E-01 (Median)	Methylation in Control	6.25E-01 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC4A9 in HIV infection			[ 6 ]
Location	3'UTR (cg14564815)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.08E+00	Statistic Test	p-value:3.36E-04; Z-score:9.67E-01
Methylation in Case	4.12E-01 (Median)	Methylation in Control	3.83E-01 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Lung adenocarcinoma	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in lung adenocarcinoma			[ 7 ]
Location	TSS1500 (cg03551019)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.03E+00	Statistic Test	p-value:4.38E-02; Z-score:7.46E-01
Methylation in Case	7.98E-01 (Median)	Methylation in Control	7.72E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in lung adenocarcinoma			[ 7 ]
Location	1stExon (cg08457872)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.03E+00	Statistic Test	p-value:2.73E-03; Z-score:-1.59E+00
Methylation in Case	8.16E-01 (Median)	Methylation in Control	8.39E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in lung adenocarcinoma			[ 7 ]
Location	Body (cg08215811)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.41E+00	Statistic Test	p-value:2.59E-03; Z-score:-1.86E+00
Methylation in Case	1.69E-01 (Median)	Methylation in Control	2.37E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in lung adenocarcinoma			[ 7 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.17E+00	Statistic Test	p-value:6.12E-03; Z-score:-1.64E+00
Methylation in Case	4.80E-01 (Median)	Methylation in Control	5.63E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC4A9 in lung adenocarcinoma			[ 7 ]
Location	3'UTR (cg14564815)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.24E+00	Statistic Test	p-value:3.48E-04; Z-score:2.58E+00
Methylation in Case	3.65E-01 (Median)	Methylation in Control	2.94E-01 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Pancretic ductal adenocarcinoma	4 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in pancretic ductal adenocarcinoma			[ 8 ]
Location	TSS1500 (cg01470323)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.30E+00	Statistic Test	p-value:4.59E-06; Z-score:-1.23E+00
Methylation in Case	1.89E-01 (Median)	Methylation in Control	2.46E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in pancretic ductal adenocarcinoma			[ 8 ]
Location	TSS200 (cg03278965)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.15E+00	Statistic Test	p-value:9.50E-05; Z-score:-7.02E-01
Methylation in Case	1.08E-01 (Median)	Methylation in Control	1.24E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in pancretic ductal adenocarcinoma			[ 8 ]
Location	1stExon (cg04711050)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.12E+00	Statistic Test	p-value:1.10E-02; Z-score:-6.45E-01
Methylation in Case	7.69E-02 (Median)	Methylation in Control	8.62E-02 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in pancretic ductal adenocarcinoma			[ 8 ]
Location	Body (cg00844950)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.04E+00	Statistic Test	p-value:3.54E-02; Z-score:1.20E-01
Methylation in Case	9.30E-02 (Median)	Methylation in Control	8.91E-02 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Papillary thyroid cancer	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in papillary thyroid cancer			[ 9 ]
Location	TSS1500 (cg03551019)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.08E+00	Statistic Test	p-value:1.31E-05; Z-score:1.41E+00
Methylation in Case	7.75E-01 (Median)	Methylation in Control	7.20E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in papillary thyroid cancer			[ 9 ]
Location	TSS200 (cg07493760)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.22E+00	Statistic Test	p-value:2.77E-09; Z-score:1.36E+00
Methylation in Case	4.43E-01 (Median)	Methylation in Control	3.63E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in papillary thyroid cancer			[ 9 ]
Location	1stExon (cg08457872)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.06E+00	Statistic Test	p-value:4.66E-04; Z-score:1.08E+00
Methylation in Case	7.83E-01 (Median)	Methylation in Control	7.40E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in papillary thyroid cancer			[ 9 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.35E+00	Statistic Test	p-value:4.41E-17; Z-score:-2.07E+00
Methylation in Case	4.54E-01 (Median)	Methylation in Control	6.12E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC4A9 in papillary thyroid cancer			[ 9 ]
Location	Body (cg08215811)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.39E+00	Statistic Test	p-value:3.27E-12; Z-score:-1.82E+00
Methylation in Case	1.12E-01 (Median)	Methylation in Control	1.56E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Systemic lupus erythematosus	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in systemic lupus erythematosus			[ 10 ]
Location	TSS1500 (cg03551019)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.00E+00	Statistic Test	p-value:3.45E-02; Z-score:-1.38E-01
Methylation in Case	9.08E-01 (Median)	Methylation in Control	9.11E-01 (Median)
Studied Phenotype	Systemic lupus erythematosus[ ICD-11:4A40.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in systemic lupus erythematosus			[ 10 ]
Location	Body (cg06660015)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.06E+00	Statistic Test	p-value:1.99E-03; Z-score:3.81E-01
Methylation in Case	4.11E-01 (Median)	Methylation in Control	3.89E-01 (Median)
Studied Phenotype	Systemic lupus erythematosus[ ICD-11:4A40.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in systemic lupus erythematosus			[ 10 ]
Location	Body (cg08215811)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.07E+00	Statistic Test	p-value:6.61E-03; Z-score:-2.95E-01
Methylation in Case	1.98E-01 (Median)	Methylation in Control	2.12E-01 (Median)
Studied Phenotype	Systemic lupus erythematosus[ ICD-11:4A40.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in systemic lupus erythematosus			[ 10 ]
Location	Body (cg18014856)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.04E+00	Statistic Test	p-value:7.69E-03; Z-score:-1.68E-01
Methylation in Case	5.49E-02 (Median)	Methylation in Control	5.72E-02 (Median)
Studied Phenotype	Systemic lupus erythematosus[ ICD-11:4A40.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC4A9 in systemic lupus erythematosus			[ 10 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.05E+00	Statistic Test	p-value:2.59E-02; Z-score:-1.64E-01
Methylation in Case	5.27E-01 (Median)	Methylation in Control	5.55E-01 (Median)
Studied Phenotype	Systemic lupus erythematosus[ ICD-11:4A40.0]
Experimental Material	Patient tissue samples
Atypical teratoid rhabdoid tumor	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in atypical teratoid rhabdoid tumor			[ 11 ]
Location	1stExon (cg08457872)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.67E+00	Statistic Test	p-value:5.45E-21; Z-score:-3.51E+00
Methylation in Case	4.35E-01 (Median)	Methylation in Control	7.26E-01 (Median)
Studied Phenotype	Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in atypical teratoid rhabdoid tumor			[ 11 ]
Location	Body (cg06660015)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.68E+00	Statistic Test	p-value:2.79E-03; Z-score:-1.04E+00
Methylation in Case	2.15E-01 (Median)	Methylation in Control	3.61E-01 (Median)
Studied Phenotype	Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in atypical teratoid rhabdoid tumor			[ 11 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.05E+00	Statistic Test	p-value:4.11E-03; Z-score:4.61E-01
Methylation in Case	8.30E-01 (Median)	Methylation in Control	7.91E-01 (Median)
Studied Phenotype	Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in atypical teratoid rhabdoid tumor			[ 11 ]
Location	Body (cg08215811)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.06E+00	Statistic Test	p-value:5.61E-03; Z-score:4.50E-01
Methylation in Case	8.01E-02 (Median)	Methylation in Control	7.55E-02 (Median)
Studied Phenotype	Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC4A9 in atypical teratoid rhabdoid tumor			[ 11 ]
Location	3'UTR (cg14564815)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.59E+00	Statistic Test	p-value:4.37E-11; Z-score:-2.44E+00
Methylation in Case	4.05E-01 (Median)	Methylation in Control	6.45E-01 (Median)
Studied Phenotype	Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]
Experimental Material	Patient tissue samples
Renal cell carcinoma	3 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in clear cell renal cell carcinoma			[ 12 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.57E+00	Statistic Test	p-value:7.55E-10; Z-score:-4.10E+00
Methylation in Case	4.61E-01 (Median)	Methylation in Control	7.22E-01 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in clear cell renal cell carcinoma			[ 12 ]
Location	Body (cg08215811)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.39E+00	Statistic Test	p-value:2.06E-04; Z-score:-1.60E+00
Methylation in Case	8.94E-02 (Median)	Methylation in Control	1.24E-01 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in clear cell renal cell carcinoma			[ 12 ]
Location	Body (cg06660015)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.16E+00	Statistic Test	p-value:2.08E-02; Z-score:8.11E-01
Methylation in Case	2.44E-01 (Median)	Methylation in Control	2.10E-01 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Panic disorder	2 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in panic disorder			[ 13 ]
Location	Body (cg06660015)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-8.44E-01	Statistic Test	p-value:1.79E-02; Z-score:-4.54E-01
Methylation in Case	-2.11E+00 (Median)	Methylation in Control	-1.78E+00 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in panic disorder			[ 13 ]
Location	Body (cg07521929)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.74E+00	Statistic Test	p-value:2.03E-02; Z-score:5.94E-01
Methylation in Case	5.86E-01 (Median)	Methylation in Control	3.37E-01 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Prostate cancer	4 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC4A9 in prostate cancer			[ 14 ]
Location	Body (cg09996840)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.28E+00	Statistic Test	p-value:2.54E-02; Z-score:-2.44E+00
Methylation in Case	4.03E-01 (Median)	Methylation in Control	5.18E-01 (Median)
Studied Phenotype	Prostate cancer[ ICD-11:2C82]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC4A9 in prostate cancer			[ 14 ]
Location	Body (cg16902190)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.08E+00	Statistic Test	p-value:2.96E-02; Z-score:1.63E+00
Methylation in Case	9.07E-01 (Median)	Methylation in Control	8.39E-01 (Median)
Studied Phenotype	Prostate cancer[ ICD-11:2C82]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC4A9 in prostate cancer			[ 14 ]
Location	Body (cg09951201)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.08E+00	Statistic Test	p-value:3.18E-02; Z-score:1.64E+00
Methylation in Case	9.06E-01 (Median)	Methylation in Control	8.41E-01 (Median)
Studied Phenotype	Prostate cancer[ ICD-11:2C82]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC4A9 in prostate cancer			[ 14 ]
Location	Body (cg15128778)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.15E+00	Statistic Test	p-value:4.79E-02; Z-score:3.34E+00
Methylation in Case	8.16E-01 (Median)	Methylation in Control	7.09E-01 (Median)
Studied Phenotype	Prostate cancer[ ICD-11:2C82]
Experimental Material	Patient tissue samples

References
1	DNA Methylation Dynamics in Urological Tumors.
2	Genome-wide Scan for Methylation Profiles in Breast Cancer
3	Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips. Epigenetics. 2013 Sep;8(9):921-34.
4	Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
5	Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
6	HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis. 2015 Nov 15;212(10):1563-73.
7	DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues
8	Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
9	Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
10	Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet. 2013;9(8):e1003678.
11	Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell. 2016 Mar 14;29(3):379-393.
12	A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma. Nat Commun. 2015 Oct 30;6:8699.
13	DNA Methylation signatures in panic disorder. Transl Psychiatry. 2017 Dec 18;7(12):1287.
14	Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array. BMC Genomics. 2014 Jan 22;15:51.

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