Drug Transporter (DT) Information

General Information of DT
DT ID DTD0381
Gene Name SLC4A10
Protein Name Sodium-driven chloride bicarbonate exchanger
Gene ID
57282
UniProt ID
Q6U841
TCDB ID
2.A.31.2.14
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6CAA_A

Identity:54.536%

Minimized Score:-1605.462 kcal/mol

Detail: Structure Info

Synonyms NBCn2; NCBE; SLC4A10; Solute carrier family 4 member 10
DT Family Anion Exchanger (AE) Family ;
Function This Electrogenic sodium/bicarbonate cotransporter Plays an important role in regulating intracellular pH and in exchange for intracellular chloride.
Endogenous Substrate(s) Cl-; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-driven chloride bicarbonate exchanger
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-driven chloride bicarbonate exchanger
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-driven chloride bicarbonate exchanger
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium-driven chloride bicarbonate exchanger
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-driven chloride bicarbonate exchanger
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-driven chloride bicarbonate exchanger
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-driven chloride bicarbonate exchanger
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-driven chloride bicarbonate exchanger
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-driven chloride bicarbonate exchanger
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sodium bicarbonate
 Approved Drug Info Metabolic acidosis 5C73 [1]
References
1 Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90.

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