Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0381 Transporter Info
Gene Name SLC4A10
Transporter Name Sodium-driven chloride bicarbonate exchanger
Gene ID
57282
UniProt ID
Q6U841

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        TCF4 

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       Transcriptional Phenomenon1

 Binding to SLC4A10 gene in glioblastoma multiforme condition [1]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC4A10 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sodium-driven chloride bicarbonate exchanger.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Direct binding to SLC4A10 gene in prostate cancer condition [2]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC4A10 gene in prostate cancer condition, which leads to a affected expression of the drug transporter Sodium-driven chloride bicarbonate exchanger.

       Transcriptional Phenomenon2

 Binding to SLC4A10 gene in prostate cancer condition [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC4A10 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium-driven chloride bicarbonate exchanger.

      Class2.3: C2H2 zinc finger factors

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        ZNF217 

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       Transcriptional Phenomenon1

 Binding to SLC4A10 gene in breast cancer condition [4]

TF Protein Name

 Zinc finger protein 217 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC4A10 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium-driven chloride bicarbonate exchanger.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        FOXM1 

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       Transcriptional Phenomenon1

 Activation of SLC4A10 gene in breast cancer condition [5]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC4A10 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium-driven chloride bicarbonate exchanger.

      Class3.5: Tryptophan cluster factors

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        FLI1 

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       Transcriptional Phenomenon1

 Direct binding to SLC4A10 gene [6]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC4A10 gene, which in turn affects the expression or function of the drug transporter Sodium-driven chloride bicarbonate exchanger.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        NFAT5 

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       Transcriptional Phenomenon1

 Direct binding to SLC4A10 gene in hyposmolality condition [7]

TF Protein Name

 Nuclear factor of activated T-cells 5 Transcription Factor Info

Studied Phenotype

 Hyposmolality [ICD11: 5C72]

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Experimental Material

 human peripheral blood mononuclear cell isolates

Detailed Description

 Nuclear factor of activated T-cells 5 (NFAT5) can directly bind to the SLC4A10 gene, which in turn affects the expression or function of the drug transporter Sodium-driven chloride bicarbonate exchanger.

      Class6.3: p53 domain factors

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        TP53 

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       Transcriptional Phenomenon1

 Binding to SLC4A10 gene in tumorigenesis condition [8]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC4A10 gene in tumorigenesis condition, which leads to an affected expression of the drug transporter Sodium-driven chloride bicarbonate exchanger.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

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       Transcriptional Phenomenon1

 Binding to SLC4A10 gene in epithelial ovarian cancer condition [9]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC4A10 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Sodium-driven chloride bicarbonate exchanger.
References
1 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
2 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
3 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
4 Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
5 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
6 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-310. (ID:ENSG00000144290)
7 NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality. J Am Soc Nephrol. 2017 Aug;28(8):2311-2321.
8 A global map of p53 transcription-factor binding sites in the human genome. Cell. 2006;124(1):207-19.
9 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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