Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0381 Transporter Info
Gene Name	SLC4A10
Transporter Name	Sodium-driven chloride bicarbonate exchanger
Gene ID	57282
UniProt ID	Q6U841

Post-Translational Modification of This DT
Overview ofSLC4A10 Modification Sites with Functional and Structural Information
Sequence	M E I K D Q G A Q M E P L L P T R N D E E A V V D R G G T R S I L K T H F E K E D L E G H R T L F I G V H V P L G G R K S H R R H R H R G H K H R K R D R E R D S G L E D G R E S P S F D T P S Q R V Q F I L G T E D D D E E H I P H D L F T E L D E I C W R E G E D A E W R E T A R W L K F E E D V E D G G E R W S K P Y V A T L S L H S L F E L R S C I L N G T V L L D M H A N T L E E I A D M V L D Q Q V S S G Q L N E D V R H R V H E A L M K Q H H H Q N Q K K L T N R I P I V R S F A D I G K K Q S E P N S M D K N A G Q V V S P Q S A P A C V E N K N D V S R E N S T V D F S K G L G G Q Q K G H T S P C G M K Q R H E K G P P H Q Q E R E V D L H F M K K I P P G A E A S N I L V G E L E F L D R T V V A F V R L S P A V L L Q G L A E V P I P T R F L F I L L G P L G K G Q Q Y H E I G R S I A T L M T D E V F H D V A Y K A K D R N D L V S G I D E F L D Q V T V L P P G E W D P S I R I E P P K N V P S Q E K R K I P A V P N G T A A H G E A E P H G G H S G P E L Q R T G R I F G G L I L D I K R K A P Y F W S D F R D A F S L Q C L A S F L F L Y C A C M S P V I T F G G L L G E A T E G R I S A I E S L F G A S M T G I A Y S L F G G Q P L T I L G S T G P V L V F E K I L F K F C K E Y G L S Y L S L R A S I G L W T A T L C I I L V A T D A S S L V C Y I T R F T E E A F A S L I C I I F I Y E A L E K L F E L S E A Y P I N M H N D L E L L T Q Y S C N C V E P H N P S N G T L K E W R E S N I S A S D I I W E N L T V S E C K S L H G E Y V G R A C G H D H P Y V P D V L F W S V I L F F S T V T L S A T L K Q F K T S R Y F P T K V R S I V S D F A V F L T I L C M V L I D Y A I G I P S P K L Q V P S V F K P T R D D R G W F V T P L G P N P W W T V I A A I I P A L L C T I L I F M D Q Q I T A V I I N R K E H K L K K G C G Y H L D L L M V A V M L G V C S I M G L P W F V A A T V L S I T H V N S L K L E S E C S A P G E Q P K F L G I R E Q R V T G L M I F I L M G S S V F M T S I L K F I P M P V L Y G V F L Y M G A S S L K G I Q F F D R I K L F W M P A K H Q P D F I Y L R H V P L R K V H L F T I I Q M S C L G L L W I I K V S R A A I V F P M M V L A L V F V R K L M D L L F T K R E L S W L D D L M P E S K K K K L E D A E K E E E Q S M L A M E D E G T V Q L P L E G H Y R D D P S V I N I S D E M S K T A L W R N L L I T A D N S K D K E S S F P S K S S P S
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	677
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC4A10 Asparagine 677 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A10			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	687
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC4A10 Asparagine 687 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC4A10			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	697
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC4A10 Asparagine 697 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	894
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC4A10 Cystine 894 has the potential to affect its expression or activity.
Phosphorylation
Serine	26 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	31
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 31 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A10			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 81 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC4A10			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	89
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 89 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC4A10			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	91
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 91 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC4A10			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	172
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 172 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC4A10			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	238
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 238 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC4A10			[6], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	247
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 247 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC4A10			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	261
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 261 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC4A10			[4], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	264
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 264 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC4A10			[6], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	276
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 276 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC4A10			[8], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	280
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 280 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC4A10			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	285
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 285 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC4A10			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	390
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 390 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC4A10			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	415
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 415 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC4A10			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	435
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 435 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence SLC4A10			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	928
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 928 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence SLC4A10			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	948
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 948 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence SLC4A10			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	949
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 949 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence SLC4A10			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1033
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 1033 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence SLC4A10			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1042
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 1042 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence SLC4A10			[19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1057
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 1057 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence SLC4A10			[20], [21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1110
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 1110 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence SLC4A10			[20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1113
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 1113 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence SLC4A10			[19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1115
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 1115 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence SLC4A10			[11], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1116
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 1116 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence SLC4A10			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1118
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Serine 1118 has the potential to affect its expression or activity.
Threonine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	230
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Threonine 230 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A10			[8], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	281
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Threonine 281 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC4A10			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	425
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Threonine 425 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC4A10			[22]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	795
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Threonine 795 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[23]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	939
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC4A10 Tyrosine 939 has the potential to affect its expression or activity.
Ubiquitination
Alanine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	185
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Alanine 185 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	407
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Alanine 407 has the potential to affect its expression or activity.
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Arginine 389 has the potential to affect its expression or activity.
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[25]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	255
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Asparagine 255 has the potential to affect its expression or activity.
Asparticacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	418
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Asparticacid 418 has the potential to affect its expression or activity.
Glutamicacid	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	215
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Glutamicacid 215 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	386
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Glutamicacid 386 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	419
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Glutamicacid 419 has the potential to affect its expression or activity.
Glycine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	376
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Glycine 376 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	388
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Glycine 388 has the potential to affect its expression or activity.
Isoleucine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Isoleucine	Modified Location	387
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Isoleucine 387 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Isoleucine	Modified Location	417
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Isoleucine 417 has the potential to affect its expression or activity.
Leucine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	375
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Leucine 375 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	378
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Leucine 378 has the potential to affect its expression or activity.
Lysine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[25]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	244
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Lysine 244 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	406
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Lysine 406 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	408
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Lysine 408 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC4A10			[26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1043
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Lysine 1043 has the potential to affect its expression or activity.
Methionine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Methionine	Modified Location	183
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Methionine 183 has the potential to affect its expression or activity.
Phenylalanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	420
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Phenylalanine 420 has the potential to affect its expression or activity.
Proline	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	377
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Proline 377 has the potential to affect its expression or activity.
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	390
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Serine 390 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	405
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Tyrosine 405 has the potential to affect its expression or activity.
Valine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC4A10			[7], [24]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	213
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC4A10 Valine 213 has the potential to affect its expression or activity.

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