General Information of Drug Transporter (DT)
DT ID DTD0388 Transporter Info
Gene Name SLC4A8
Protein Name Electroneutral sodium bicarbonate exchanger 1
Gene ID
9498
UniProt ID
Q2Y0W8
3D Structure

Modelled Stucture

Method:Homology modeling

Teplate PDB:6CAA_A

Identity:56.484%

Minimized Score:-1548.413

Detail: Structure Info

Inter-species Structural Differences (ISD)
Mus musculus (Mouse)
        Gene Name Slc4a8
        UniProt ID
Q8JZR6
        UniProt Entry
S4A8_MOUSE
        3D Structure

Method:Homology modeling

Teplate PDB:6CAA_A

Sequence Length:912

Identity:56.21%

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        Performance Minimized Score -1379.191 kcal/mol
Ramachandra Favored

Poor

QMEANBrane Quality

Medium

        Ramachandran Plot

Ramz Z Score:-2.1 ±0.25

Residues in Favored Region:861

Ramachandran favored:94.62%

Number of Outliers:7

Ramachandran outliers:0.77%

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        Local Quality

QMEANBrane Score:0.72

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Rattus norvegicus (Rat)
        Gene Name Slc4a8
        UniProt ID
Q6RVG2
        UniProt Entry
S4A8_RAT
        3D Structure

Method:Homology modeling

Teplate PDB:6CAA_A

Sequence Length:916

Identity:53.87%

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        Performance Minimized Score -1565.432 kcal/mol
Ramachandra Favored

Poor

QMEANBrane Quality

Medium

        Ramachandran Plot

Ramz Z Score:-1.29 ±0.26

Residues in Favored Region:865

Ramachandran favored:94.64%

Number of Outliers:10

Ramachandran outliers:1.09%

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        Local Quality

QMEANBrane Score:0.72

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References
1 Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE. Nat Commun. 2021;12(1):5690.

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