Drug Transporter (DT) Information

General Information of DT
DT ID DTD0361
Gene Name SLC43A2
Protein Name L-type amino acid transporter 4
Gene ID
124935
UniProt ID
Q8N370
TCDB ID
2.A.1.44.2
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms LAT4; Large neutral amino acids transporter small subunit 4; SLC43A2; Solute carrier family 43 member 2
DT Family Major Facilitator Superfamily (MFS)
L-Amino Acid Transporter-3 (LAT3) Family
Tissue Specificity Detected in several tissues with higherexpression in placenta, kidney and peripheral blood leukocytes. Inthe kidney, is detected in epithelial cells of the distal tubuleand collecting duct. In the intestine, is expressed mainly incrypt cells of the intestinal microvilli and epithelial cells inthe base of the villus.
Function This sodium-, chloride-, and pH-independent transporter is for large neutral amino acids.
Endogenous Substrate(s) Amino acid alcohols
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of L-type amino acid transporter 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of L-type amino acid transporter 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of L-type amino acid transporter 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of L-type amino acid transporter 4
Microbiota Influence (MBI)

(β) Post-translational Modification of L-type amino acid transporter 4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of L-type amino acid transporter 4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of L-type amino acid transporter 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of L-type amino acid transporter 4
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of L-type amino acid transporter 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of L-type amino acid transporter 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-phenylalanine
 Approved Drug Info Dietary shortage 5B7Z [1]

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-leucine
 Phase 2 Drug Info Major depressive disorder 6A70.3 [1]

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-valine
 Preclinical Drug Info Traumatic brain injury NA07.Z [1]
References
1 Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542.

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