Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00266
|
|||||
| Drug Name |
L-phenylalanine
|
|||||
| Synonyms |
(2S)-2-amino-3-phenylpropanoic acid; (L)-Phenylalanine; (S)-(-)-Phenylalanine; (S)-2-Amino-3-phenylpropanoic acid; (S)-2-Amino-3-phenylpropionic acid; (S)-Phenylalanine; (S)-alpha-Amino-benzenepropanoic acid; (S)-alpha-Amino-beta-phenylpropionic acid; (S)-alpha-Aminohydrocinnamic acid; 1F9436B3-8B0D-4AC6-A004-4249B0BDA436; 3-Phenyl-L-alanine; 3-Phenylalanine; 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-formamidopropanoic acid; Alpha-Aminohydrocinnamic acid; Antibiotic FN 1636; Beta-Phenyl-L-alanine; Beta-Phenylalanine; CB 3208; Endophenyl; Fenilalanina; Fenilalanina [Spanish]; H-Phe-OH; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)-N-formylalanine; L-Antibiotic FN 1636; L-PHENYL ALANINE (SEE ALSO 22839-47-0, ASPARTAME; L-PHENYLALININE; L-Phenylalanine (JP15); L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-formyl-(9CI); N-Formyl-L-p-sarcolysin; N-Formyl-L-sarcolysin; N-Formylmelphalan; NCI9959; Phe; Phenylalanine; Phenylalanine (USP/INN); Phenylalanine (VAN); Phenylalanine [USAN:INN:JAN]; Phenylalaninum; Phenylalaninum [Latin]
|
|||||
| Drug Type |
Small molecular drug
|
|||||
| Indication | Dietary shortage [ICD11:5B7Z] | Approved | [1] | |||
| Therapeutic Class |
Dietary supplement
|
|||||
| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
C9H11NO2
|
|||||
| Canonical SMILES |
C1=CC=C(C=C1)CC(C(=O)O)N
|
|||||
| InChI |
InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
|
|||||
| InChIKey |
COLNVLDHVKWLRT-QMMMGPOBSA-N
|
|||||
| CAS Number |
CAS 63-91-2
|
|||||
| Pharmaceutical Properties | Molecular Weight | 165.19 | Topological Polar Surface Area | 63.3 | ||
| Heavy Atom Count | 12 | Rotatable Bond Count | 3 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
-1.5
|
|||||
| PubChem CID | ||||||
| PubChem SID |
10531434
,11457628
,11459655
,11528323
,11532528
,14710668
,15219430
,24770335
,24770338
,24770342
,24887247
,24898274
,24898657
,24898971
,24901797
,26651814
,26702643
,26748791
,26748792
,26753740
,29225143
,3134198
,3379
,4252550
,46391851
,46393329
,46505708
,50107465
,57323218
,57578102
,57652717
,57654567
,57655097
,584667
,6436530
,78164833
,7847089
,7889851
,81044023
,81044025
,81044569
,81067307
,81067312
,8144203
,8153851
,822460
,824902
,832928
,838754
,841094
|
|||||
| ChEBI ID |
ChEBI:17295
|
|||||
| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | LAT2 | Transporter Info | L-type amino acid transporter 2 | Substrate | [2] | |
| LAT3 | Transporter Info | L-type amino acid transporter 3 | Substrate | [3] | ||
| LAT4 | Transporter Info | L-type amino acid transporter 4 | Substrate | [4] | ||
| Drug-Transporter Activity Data | ||||||
| Drug-Transporter Activity Data | LAT2 | Transporter Info | Km =12.2 microM | Xenopus oocytes-LAT2 | [2] | |
| References | ||||||
| 1 | L-phenylalanine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Quantifying the relative contributions of different solute carriers to aggregate substrate transport. Sci Rep. 2017 Jan 16;7:40628. | |||||
| 3 | Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45. | |||||
| 4 | Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.