Drug Transporter (DT) Information

General Information of DT
DT ID DTD0360
Gene Name SLC43A1
Protein Name L-type amino acid transporter 3
Gene ID
8501
UniProt ID
O75387
TCDB ID
2.A.1.44.1
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms LAT3; Large neutral amino acids transporter small subunit 3; PB39; POV1; Prostate cancer overexpressed gene 1 protein; R00504; SLC43A1; Solute carrier family 43 member 1
DT Family Major Facilitator Superfamily (MFS)
L-Amino Acid Transporter-3 (LAT3) Family
Function This sodium-independent transporter is for neutral amino acids and has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.
Endogenous Substrate(s) Amino acid alcohols; 3'-Iodotyrosine
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of L-type amino acid transporter 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of L-type amino acid transporter 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of L-type amino acid transporter 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of L-type amino acid transporter 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of L-type amino acid transporter 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of L-type amino acid transporter 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of L-type amino acid transporter 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of L-type amino acid transporter 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of L-type amino acid transporter 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-phenylalanine
 Approved Drug Info Dietary shortage 5B7Z [1]

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-leucine
 Phase 2 Drug Info Major depressive disorder 6A70.3 [1]

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
L-valine
 Preclinical Drug Info Traumatic brain injury NA07.Z [1]
References
1 Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45.

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