Drug Information

General Information
Drug ID
DR00303
Drug Name
L-leucine
Synonyms
(2S)-2-amino-4-methylpentanoic acid; (2S)-alpha-leucine; (S)-(+)-Leucine; (S)-2-Amino-4-methylpentanoic acid; (S)-2-Amino-4-methylvaleric acid; (S)-Leucine; 2-amino-4-methylvaleric acid; 61-90-5; H-Leu-OH; L-(-)-2-Amino-4-methylpentanoic acid; L-Leuzin; L-Norvaline, 4-methyl-; L-alpha-Aminoisocaproic acid; L-leucin; LEUCINE, L-; Leucin; Leucin [German]; Leucina [INN-Spanish]; Leucina [Latin,Spanish]; Leucine (VAN); Leucine [USAN:INN]; Leucinum; Leucinum [INN-Latin]; alpha-Aminoisocaproic acid; leu; leucine
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD11:6A70.3] Phase 2 [1]
Structure
3D MOL 2D MOL
Formula
C6H13NO2
Canonical SMILES
CC(C)CC(C(=O)O)N
InChI
InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKey
ROHFNLRQFUQHCH-YFKPBYRVSA-N
CAS Number
CAS 61-90-5
Pharmaceutical Properties Molecular Weight 131.17 Topological Polar Surface Area 63.3
Heavy Atom Count 9 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
XLogP
-1.5
PubChem CID
6106
PubChem SID
10317235 ,10530134 ,11459278 ,11459418 ,15146625 ,15218991 ,24874858 ,24886442 ,24896388 ,24896488 ,24896510 ,24901619 ,26651805 ,29225114 ,3423 ,4253012 ,46391850 ,46392412 ,46393330 ,46507163 ,46507999 ,48416162 ,49747925 ,49835907 ,49988821 ,50108366 ,57323191 ,57581300 ,57581304 ,57651866 ,57654329 ,57654969 ,57654972 ,57654976 ,595259 ,6436525 ,6436533 ,6436536 ,6436708 ,7847098 ,7888630 ,80033595 ,8025197 ,81044540 ,81055047 ,8143308 ,8153821 ,832925 ,838753 ,841561
ChEBI ID
ChEBI:15603
TTD Drug ID
D0W4MZ
DT(s) Transporting This Drug LAT1 Transporter Info L-type amino acid transporter 1 Substrate [2]
LAT3 Transporter Info L-type amino acid transporter 3 Substrate [3]
LAT4 Transporter Info L-type amino acid transporter 4 Substrate [4]
References
1 ClinicalTrials.gov (NCT03079297) Rapid Antidepressant Effects of Leucine
2 Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34.
3 Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45.
4 Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542.

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