Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0269 | ||||
| Gene Name | SLC30A1 | ||||
| Protein Name | Zinc transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | SLC30A1; Solute carrier family 30 member 1; ZNT1; ZRC1; ZnT-1 | ||||
| DT Family | Cation Diffusion Facilitator (CDF) Family ; | ||||
| Function | This transporter may be involved in zinc transport out of the cell. | ||||
| Endogenous Substrate(s) | Zn2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Zinc transporter 1 |
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(β) Cell Distribution Level of Zinc transporter 1 |
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(γ) Organelle Distribution Level of Zinc transporter 1 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Zinc transporter 1 |
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(β) Post-translational Modification of Zinc transporter 1 |
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(γ) Transcriptional Regulation of Zinc transporter 1 |
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(δ) Epigenetic Regulation of Zinc transporter 1 |
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(ε) Exogenous Modulation of Zinc transporter 1 |
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Structural Variability Data of This DT |
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(α) Mutation-induced Structural Variation |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Zinc transporter 1 |
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(β) Disease-specific Protein Abundances of Zinc transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Withdrawn, Discontinued or Preclinical Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Zinc salts
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Preclinical | Drug Info | Arthritis | FA5Z | [1] |
| References | |||||
| 1 | Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. J Nutr. 2008 Nov;138(11):2076-83. | ||||
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