Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0269 Transporter Info
Gene Name	SLC30A1
Transporter Name	Zinc transporter 1
Gene ID	7779
UniProt ID	Q9Y6M5

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Approved Drug
Sulindac	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sulindac increases the expression of SLC30A1		[2]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of SLC30A1		[3]
Zinc Acetate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc Acetate increases the expression of SLC30A1		[4]
Nitroprusside	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nitroprusside increases the expression of SLC30A1		[5]
Irinotecan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Irinotecan inhibits the expression of SLC30A1		[6]
Phenobarbital	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenobarbital affects the expression of SLC30A1		[7]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of SLC30A1		[8]
Amiodarone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Amiodarone increases the expression of SLC30A1		[10]
Isotretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isotretinoin inhibits the expression of SLC30A1		[11]
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Decitabine affects the expression of SLC30A1		[12]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC30A1		[14]
Cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cupric chloride increases the expression of SLC30A1		[15]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin affects the expression of SLC30A1		[16]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC30A1		[17]
DT Modulation2	Acetaminophen results in increased expression of SLC30A1 mRNA		[65]
Regulation Mechanism			Transcription Factor Info
Vorinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vorinostat increases the expression of SLC30A1		[18]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC30A1		[19]
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dronabinol inhibits the expression of SLC30A1		[20]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of SLC30A1		[21]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC30A1		[22]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC30A1		[23]
Cannabidiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cannabidiol increases the expression of SLC30A1		[24]
Cisplatin	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin increases the expression of SLC30A1		[28]
Ethinyl Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol affects the expression of SLC30A1		[29]
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC30A1		[30]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC30A1		[31]
Arsenic Trioxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC30A1		[32]
Gallium nitrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gallium nitrate induces the activity of SLC30A1		[33]
Drug Marketed but not Approved by US FDA
Silver Nitrate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver Nitrate increases the expression of SLC30A1		[9]
Demecolcine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Demecolcine increases the expression of SLC30A1		[13]
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rotenone increases the expression of SLC30A1		[25]
Zinc Sulfate	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc Sulfate increases the expression of SLC30A1		[26]
Zinc chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc chloride increases the expression of SLC30A1		[27]
Drug in Phase 3 Trial
Curcumin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Curcumin increases the expression of SLC30A1		[38]
Epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Epigallocatechin gallate inhibits the expression of SLC30A1		[42]
Drug in Phase 2 Trial
Colforsin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Colforsin increases the expression of SLC30A1		[36]
Genistin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Genistin increases the expression of SLC30A1		[37]
STA-4783	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	STA-4783 increases the expression of SLC30A1		[40]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC30A1		[52]
Motexafin gadolinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Motexafin gadolinium increases the expression of SLC30A1		[4]
Genistein	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLC30A1		[58]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC30A1		[43]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC30A1		[45]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC30A1		[61]
Drug in Preclinical Test
Gardiquimod	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gardiquimod increases the expression of SLC30A1		[50]
Investigative Drug
PCI-5002	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI-5002 increases the expression of SLC30A1		[39]
Coumestrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol inhibits the expression of SLC30A1		[41]
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of SLC30A1		[48]
Patented Pharmaceutical Agent
AM-251	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	AM-251 increases the expression of SLC30A1		[35]
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG-001 inhibits the expression of SLC30A1		[47]
GSK-J4	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	GSK-J4 increases the expression of SLC30A1		[54]
Natural Product
Deguelin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Deguelin increases the expression of SLC30A1		[25]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC30A1		[57]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Caffeine results in decreased phosphorylation of SLC30A1 protein		[76]
Regulation Mechanism			Transcription Factor Info
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Jinfukang inhibits the expression of SLC30A1		[49]
Plant Extract
Grape Seed Proanthocyanidins	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Grape Seed Proanthocyanidins inhibits the expression of SLC30A1		[42]
Environmental toxicant
Zinc	13 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc induces the activity of SLC30A1		[1]
Cell System	Human prostate cancer cell lines (LNCaP and PC-3)
Zinc Oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc Oxide increases the expression of SLC30A1		[53]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC30A1		[44]
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLC30A1 gene		[66]
Regulation Mechanism			Transcription Factor Info
ochratoxin A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ochratoxin A promotes the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA		[91]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Zinc inhibits the reaction ochratoxin A promotes the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA		[91]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Cadmium	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the expression of SLC30A1		[34]
Regulation Mechanism	via enhancement of Metal regulatory transcription factor 1 (MTF1)		Transcription Factor Info
Cell System	Wistar rats
Oxyquinoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxyquinoline inhibits the expression of SLC30A1		[43]
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Formaldehyde increases the expression of SLC30A1		[13]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide increases the expression of SLC30A1		[55]
Antimycin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Antimycin A increases the expression of SLC30A1		[25]
Carcinogen
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC30A1 protein		[63]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC30A1 mRNA		[72]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC30A1 protein		[63]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Cadmium results in increased expression of and affects the localization of SLC30A1 protein		[73]
Regulation Mechanism			Transcription Factor Info
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate increases the expression of SLC30A1		[13]
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC30A1		[43]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC30A1 mRNA		[67]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos inhibits the expression of SLC30A1		[51]
Health and Environmental Toxicant
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate increases the expression of SLC30A1		[46]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the expression of SLC30A1		[56]
Nanoparticle
Silver nanoparticle	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver nanoparticle increases the expression of SLC30A1		[60]
Chemical Compound
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC30A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC30A1 protein results in increased transport of Zinc		[101]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	SLC30A1 protein results in increased uptake of Zinc		[102]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Zinc co-treated with motexafin gadolinium results in increased expression of SLC30A1 mRNA		[88]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC30A1 mRNA		[91]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Zinc deficiency results in decreased expression of SLC30A1 mRNA		[91]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Zinc inhibits the reaction ochratoxin A promotes the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA		[91]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Zinc results in decreased expression of SLC30A1 mRNA		[103]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	Zinc results in decreased expression of SLC30A1 protein		[103]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	Zinc results in increased expression of and affects the localization of SLC30A1 protein		[73]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	Zinc results in increased expression of SLC30A1 mRNA		[104]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	Zinc results in increased expression of SLC30A1 protein		[104]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	motexafin gadolinium affects the reaction Zinc Acetate results in increased expression of SLC30A1 mRNA		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Zinc Acetate affects the reaction motexafin gadolinium results in increased expression of SLC30A1 mRNA		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction Nitroprusside results in increased expression of SLC30A1 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Zinc Sulfate promotes the reaction Nitroprusside results in increased expression of SLC30A1 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	MTF1 mutant form inhibits the reaction Silver Nitrate results in increased expression of SLC30A1 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	MTF1 mutant form inhibits the reaction Zinc Sulfate results in increased expression of SLC30A1 mRNA		[106]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	PTEN mutant form inhibits the reaction Zinc Sulfate results in increased expression of SLC30A1 mRNA		[106]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Zinc Sulfate promotes the reaction Nitroprusside results in increased expression of SLC30A1 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cisplatin affects the expression of SLC30A1 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cisplatin results in decreased susceptibility to Cisplatin which results in increased expression of SLC30A1 mRNA		[79]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC30A1 mRNA		[100]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	SLC30A1 gene mutant form affects the susceptibility to Arsenic Trioxide		[68]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Genistein affects the expression of SLC30A1 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC30A1 promoter		[69]
Regulation Mechanism			Transcription Factor Info
Cupric oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cupric oxide increases the expression of SLC30A1		[59]
1-Butanol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC30A1 mRNA		[62]
Regulation Mechanism			Transcription Factor Info
2-bromopalmitate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC30A1 protein		[63]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC30A1 mRNA		[64]
Regulation Mechanism			Transcription Factor Info
Acetylcysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction elesclomol results in increased expression of SLC30A1 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
AM 251	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	AM 251 results in increased expression of SLC30A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate results in decreased expression of SLC30A1 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC30A1 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of SLC30A1 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
bisphenol AF	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol AF results in increased expression of SLC30A1 protein		[71]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC30A1 protein		[63]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC30A1 mRNA		[72]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC30A1 protein		[63]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Cadmium Chloride results in increased expression of SLC30A1 mRNA		[74]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Cadmium Chloride results in increased expression of SLC30A1 protein		[75]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC30A1 gene		[77]
Regulation Mechanism			Transcription Factor Info
chromium hexavalent ion	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in increased expression of SLC30A1 mRNA		[78]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride affects the expression of SLC30A1 mRNA		[80]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	cobaltous chloride results in increased expression of SLC30A1 mRNA		[81]
Regulation Mechanism			Transcription Factor Info
Copper	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Disulfiram binds to Copper which results in decreased expression of SLC30A1 mRNA		[82]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NSC 689534 binds to Copper which results in increased expression of SLC30A1 mRNA		[83]
Regulation Mechanism			Transcription Factor Info
cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric chloride results in increased expression of SLC30A1 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
cupric oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric oxide results in increased expression of SLC30A1 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
Dactinomycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dactinomycin co-treated with nutlin 3 results in increased expression of SLC30A1 protein		[84]
Regulation Mechanism			Transcription Factor Info
deguelin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	deguelin results in increased expression of SLC30A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in decreased expression of SLC30A1 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
Disulfiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Disulfiram binds to Copper which results in decreased expression of SLC30A1 mRNA		[82]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
elesclomol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction elesclomol results in increased expression of SLC30A1 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	elesclomol results in increased expression of SLC30A1 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
epigallocatechin gallate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	epigallocatechin gallate inhibits the reaction zinc chloride results in increased expression of SLC30A1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	epigallocatechin gallate results in decreased expression of SLC30A1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	potassium chromate(VI) co-treated with epigallocatechin gallate results in increased expression of SLC30A1 mRNA		[85]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in increased phosphorylation of SLC30A1 protein		[86]
Regulation Mechanism			Transcription Factor Info
gardiquimod	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	gardiquimod results in increased expression of SLC30A1 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Protein Kinase Inhibitors inhibits the reaction gardiquimod results in increased expression of SLC30A1 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
Gasoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC30A1 mRNA		[62]
Regulation Mechanism			Transcription Factor Info
genistin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	genistin analog results in increased expression of SLC30A1 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in decreased expression of SLC30A1 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in increased expression of SLC30A1 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in increased expression of SLC30A1 mRNA		[87]
Regulation Mechanism			Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in increased expression of SLC30A1 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
motexafin gadolinium	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	motexafin gadolinium affects the reaction Zinc Acetate results in increased expression of SLC30A1 mRNA		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	motexafin gadolinium results in increased expression of SLC30A1 mRNA		[88]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Zinc Acetate affects the reaction motexafin gadolinium results in increased expression of SLC30A1 mRNA		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Zinc co-treated with motexafin gadolinium results in increased expression of SLC30A1 mRNA		[88]
Regulation Mechanism			Transcription Factor Info
Naphthoquinones	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Naphthoquinones results in increased expression of SLC30A1 mRNA		[89]
Regulation Mechanism			Transcription Factor Info
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction Nitroprusside results in increased expression of SLC30A1 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA		[90]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ochratoxin A promotes the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA		[91]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC30A1 mRNA		[91]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Zinc inhibits the reaction ochratoxin A promotes the reaction N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA		[91]
Regulation Mechanism			Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in increased expression of SLC30A1 mRNA		[83]
Regulation Mechanism			Transcription Factor Info
nutlin 3	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dactinomycin co-treated with nutlin 3 results in increased expression of SLC30A1 protein		[84]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC30A1 mRNA		[92]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Okadaic Acid results in increased expression of SLC30A1 protein		[92]
Regulation Mechanism			Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC30A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in increased expression of SLC30A1 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
PCI 5002	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI 5002 co-treated with Zinc results in increased expression of SLC30A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	PCI 5002 results in increased expression of SLC30A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in decreased expression of SLC30A1 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
perfluorooctanoic acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in decreased expression of SLC30A1 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	perfluorooctanoic acid results in increased expression of SLC30A1 mRNA		[93]
Regulation Mechanism			Transcription Factor Info
picoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	picoxystrobin results in increased expression of SLC30A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in increased expression of SLC30A1 mRNA		[85]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	potassium chromate(VI) results in increased expression of SLC30A1 mRNA		[85]
Regulation Mechanism			Transcription Factor Info
propionaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	propionaldehyde results in increased expression of SLC30A1 mRNA		[94]
Regulation Mechanism			Transcription Factor Info
pyrachlostrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pyrachlostrobin results in increased expression of SLC30A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
Silver	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver results in increased expression of SLC30A1 mRNA		[95]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of SLC30A1 gene		[96]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in decreased expression of SLC30A1 mRNA		[97]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC30A1 mRNA		[67]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium arsenite results in increased expression of SLC30A1 mRNA		[98]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in increased expression of SLC30A1 mRNA		[99]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in increased expression of SLC30A1 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
zinc chloride	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	epigallocatechin gallate inhibits the reaction zinc chloride results in increased expression of SLC30A1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	zinc chloride inhibits the reaction Grape Seed Proanthocyanidins results in decreased expression of SLC30A1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	zinc chloride results in increased expression of SLC30A1 mRNA		[105]
Regulation Mechanism			Transcription Factor Info
zinc chromate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in increased expression of SLC30A1 mRNA		[78]
Regulation Mechanism			Transcription Factor Info
Ziram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ziram results in increased expression of SLC30A1 mRNA		[87]
Regulation Mechanism			Transcription Factor Info

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