| General Information of DT | |||||
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| DT ID | DTD0231 | ||||
| Gene Name | SLC26A3 | ||||
| Protein Name | Chloride anion exchanger | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:5DOW_B; 5EZB_A; 6RTC_A Identity:80.952%;40.541%;38.061% Minimized Score:-1510.311 kcal/mol Detail: Structure Info |
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| Synonyms | CLD; DRA; Down-regulated in adenoma; Protein DRA; SLC26A3; Solute carrier family 26 member 3 | ||||
| DT Family | Sulfate Permease (SULP) Family ; | ||||
| Function | This transporter mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. | ||||
| Endogenous Substrate(s) | Cl- | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Chloride anion exchanger |
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(β) Cell Distribution Level of Chloride anion exchanger |
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(γ) Organelle Distribution Level of Chloride anion exchanger |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Chloride anion exchanger |
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(β) Post-translational Modification of Chloride anion exchanger |
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(γ) Transcriptional Regulation of Chloride anion exchanger |
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(δ) Epigenetic Regulation of Chloride anion exchanger |
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(ε) Exogenous Modulation of Chloride anion exchanger |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Chloride anion exchanger |
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(β) Disease-specific Protein Abundances of Chloride anion exchanger |
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(γ) Species- and Tissue-specific DT Abundances |
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