General Information of Drug Transporter (DT)
DT ID DTD0231 Transporter Info
Gene Name SLC26A3
Protein Name Chloride anion exchanger
Gene ID
1811
UniProt ID
P40879
3D Structure

Modelled Stucture

Method:Homology modeling

Teplate PDB:5DOW_B; 5EZB_A; 6RTC_A

Identity:80.952%;40.541%;38.061%

Minimized Score:-1510.311

Detail: Structure Info

Inter-species Structural Differences (ISD)
Mus musculus (Mouse)
        Gene Name Slc26a3
        UniProt ID
Q9WVC8
        UniProt Entry
S26A3_MOUSE
        3D Structure

Method:Homology modeling

Teplate PDB:7CH1_A

Sequence Length:704

Identity:35.471%

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        Performance Minimized Score -1613.251 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

Medium

        Ramachandran Plot

Ramz Z Score:-0.78 ±0.3

Residues in Favored Region:679

Ramachandran favored:96.72%

Number of Outliers:2

Ramachandran outliers:0.28%

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        Local Quality

QMEANBrane Score:0.78

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        Experimental Structures of This Model Oganism
                PDB ID Scanning Method Resolution Expression System Details Ref
                5DOW X-ray 1.7 Å Escherichia coli
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[ 1]
Structure
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Corresponding chain B/D/F/H
Sequence Length 563-583 Mutation Yes
Rattus norvegicus (Rat)
        Gene Name Slc26a3
        UniProt ID
Q924C9
        UniProt Entry
S26A3_RAT
        3D Structure

Method:Homology modeling

Teplate PDB:7CH1_A

Sequence Length:704

Identity:36.066%

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        Performance Minimized Score -1767.387 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

Medium

        Ramachandran Plot

Ramz Z Score:-0.67 ±0.3

Residues in Favored Region:679

Ramachandran favored:96.72%

Number of Outliers:3

Ramachandran outliers:0.43%

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        Local Quality

QMEANBrane Score:0.78

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References
1 Solution of the structure of a calmodulin-peptide complex in a novel configuration from a variably twinned data set. Acta Crystallogr D Struct Biol. 2017 Jan 1;73(Pt 1):22-31.

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