Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0231 Transporter Info
Gene Name SLC26A3
Transporter Name Chloride anion exchanger
Gene ID
1811
UniProt ID
P40879

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        FOS 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A3 gene in colon cancer condition [1]

TF Protein Name

 Protein c-Fos Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 Protein c-Fos (FOS) has been reported to activate the transcription of SLC26A3 gene in colon cancer condition, which leads to an increased expression of the drug transporter Chloride anion exchanger.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A3 gene in prostate cancer condition [2]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC26A3 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Chloride anion exchanger.

       Transcriptional Phenomenon2

 Binding to SLC26A3 gene in prostate cancer condition [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC26A3 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Chloride anion exchanger.

        HNF4A 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A3 gene in health condition [4]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC26A3 gene in health condition, which leads to an affected expression of the drug transporter Chloride anion exchanger.

       Transcriptional Phenomenon2

 Direct binding to SLC26A3 gene [5]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) can directly bind to the SLC26A3 gene, which in turn affects the expression or function of the drug transporter Chloride anion exchanger.

        NR3C1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A3 gene in ER(-) breast cancer condition [6]

TF Protein Name

 Glucocorticoid receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC26A3 gene in ER(-) breast cancer condition, which leads to an increased expression of the drug transporter Chloride anion exchanger.

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A3 gene in megakaryocytes condition [7]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC26A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Chloride anion exchanger.

       Transcriptional Phenomenon2

 Activation of SLC26A3 gene in health condition [8]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Related DT Changes

 Up regulating

Detailed Description

 Erythroid transcription factor (GATA1), influenced by the dietary food metabolite from Host unspecified microbiota, has been reported to activate the transcription of SLC26A3 gene in health condition, which leads to an increased expression of the drug transporter Chloride anion exchanger.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A3 gene in colon cancer condition [9]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Transcriptional repressor protein YY1 (YY1) has been reported to activate the transcription of SLC26A3 gene in colon cancer condition, which leads to an increased expression of the drug transporter Chloride anion exchanger.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        HNF1A 

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       Transcriptional Phenomenon1

 Activation of SLC26A3 gene in congenital chloride diarrhoea condition [10]

TF Protein Name

 Hepatocyte nuclear factor 1-alpha Transcription Factor Info

Studied Phenotype

 Congenital chloride diarrhoea [ICD11: DA90.1]

Tissue

 Small intestine

Related DT Changes

 Up regulating

Experimental Material

 Hnf1b KO mice

Detailed Description

 Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of SLC26A3 gene in congenital chloride diarrhoea condition, which leads to an increased expression of the drug transporter Chloride anion exchanger.

      Class3.3: Fork head / winged helix factors

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        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A3 gene in prostate cancer condition [11]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC26A3 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Chloride anion exchanger.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A3 gene [12]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC26A3 gene, which in turn affects the expression or function of the drug transporter Chloride anion exchanger.

      Class3.5: Tryptophan cluster factors

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        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC26A3 gene in burkitt lymphoma condition [13]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Studied Phenotype

 Burkitt lymphoma [ICD11: 2A85]

Tissue

 Blood

Related DT Changes

 Up regulating

Experimental Material

 Human EBV-related Burkitt lymphoma cells (Raji)

Detailed Description

 Protein C-ets-1 (ETS1) has been reported to activate the transcription of SLC26A3 gene in burkitt lymphoma condition, which leads to an increased expression of the drug transporter Chloride anion exchanger.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC26A3 gene [14]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC26A3 gene, which in turn affects the expression or function of the drug transporter Chloride anion exchanger.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC26A3 gene in glioblastoma multiforme condition [15]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC26A3 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Chloride anion exchanger.
References
1 LPA stimulates intestinal DRA gene transcription via LPA2 receptor, PI3K/AKT, and c-Fos-dependent pathway. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 15;302(6):G618-27.
2 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
3 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
4 Mapping of HNF4alpha target genes in intestinal epithelial cells. BMC Gastroenterol. 2009;9:68.
5 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
6 Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 2011;71(20):6360-70.
7 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
8 Mechanisms of the intestinal and urinary microbiome in kidney stone disease. Nat Rev Urol. 2022 Dec;19(12):695-707.
9 Molecular cloning and promoter analysis of downregulated in adenoma (DRA). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G923-34.
10 Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium. Development. 2010 May;137(9):1573-82.
11 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
12 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
13 Ets-1 activates the DRA promoter in B cells. Mol Cell Biol. 1994 Nov;14(11):7314-21.
14 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
15 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.

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