Drug Transporter (DT) Information

General Information of DT
DT ID DTD0188
Gene Name SLC25A27
Protein Name Mitochondrial uncoupling protein 4
Gene ID
9481
UniProt ID
O95847
TCDB ID
2.A.29.24.3
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:2LCK_A

Identity:34.459%

Minimized Score:-418.536 kcal/mol

Detail: Structure Info

Synonyms SLC25A27; Solute carrier family 25 member 27; UCP 4; UCP4; UNQ772/PRO1566
DT Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Found in adult and fetal brain. Present inmost of the brain tissues, with low levels in spinal chord, corpuscallosum and substantia nigra.
Function This transporter is mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. It may play a role in thermoregulatory heat production and metabolism in brain.
Endogenous Substrate(s) H+; Cl-
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Mitochondrial uncoupling protein 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Mitochondrial uncoupling protein 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Mitochondrial uncoupling protein 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Mitochondrial uncoupling protein 4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Mitochondrial uncoupling protein 4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Mitochondrial uncoupling protein 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Mitochondrial uncoupling protein 4
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Mitochondrial uncoupling protein 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Mitochondrial uncoupling protein 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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