Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0188 Transporter Info
Gene Name SLC25A27
Transporter Name Mitochondrial uncoupling protein 4
Gene ID
9481
UniProt ID
O95847

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        BACH2 

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       Transcriptional Phenomenon1

 Direct binding to SLC25A27 gene [1]

TF Protein Name

 Transcription regulator protein BACH2 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription regulator protein BACH2 (BACH2) can directly bind to the SLC25A27 gene, which in turn affects the expression or function of the drug transporter Mitochondrial uncoupling protein 4.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A27 gene [2]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A27 gene, which in turn affects the expression or function of the drug transporter Mitochondrial uncoupling protein 4.

      Class1.2: Basic helix-loop-helix factors

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        TCF4 

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       Transcriptional Phenomenon1

 Binding to SLC25A27 gene in glioblastoma multiforme condition [3]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC25A27 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Mitochondrial uncoupling protein 4.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

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       Transcriptional Phenomenon1

 Activation of SLC25A27 gene in health condition [4]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Embryo

Related DT Changes

 Up regulating

Experimental Material

 AB-Tuebingen zebrafish

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to activate the transcription of SLC25A27 gene in health condition, which leads to an increased expression of the drug transporter Mitochondrial uncoupling protein 4.

      Class2.3: C2H2 zinc finger factors

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        CTCF 

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       Transcriptional Phenomenon1

 Direct binding to SLC25A27 gene [2]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC25A27 gene, which in turn affects the expression or function of the drug transporter Mitochondrial uncoupling protein 4.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A27 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A27 gene, which in turn affects the expression or function of the drug transporter Mitochondrial uncoupling protein 4.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        NANOG 

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       Transcriptional Phenomenon1

 Activation of SLC25A27 gene in HESC condition [5]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLC25A27 gene in HESC condition, which leads to an increased expression of the drug transporter Mitochondrial uncoupling protein 4.

      Class3.5: Tryptophan cluster factors

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        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A27 gene [6]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Kidney; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC25A27 gene, which in turn affects the expression or function of the drug transporter Mitochondrial uncoupling protein 4.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A27 gene [7]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A27 gene, which in turn affects the expression or function of the drug transporter Mitochondrial uncoupling protein 4.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        NFKB1 

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       Transcriptional Phenomenon1

 Activation of SLC25A27 gene in brain neuroblastoma condition [8]

TF Protein Name

 Nuclear factor NF-kappa-B p105 subunit Transcription Factor Info

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Human neuroblastoma cells (SH-SY5Y)

Detailed Description

 Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to activate the transcription of SLC25A27 gene in brain neuroblastoma condition, which leads to an increased expression of the drug transporter Mitochondrial uncoupling protein 4.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-332. (ID:ENSG00000153291)
3 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
4 Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Mol Cell Biol. 2011 Apr;31(7):1344-56.
5 Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem. 2011;286(2):1037-45.
6 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
7 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
8 Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity. Free Radic Biol Med. 2010 Jul 15;49(2):192-204.

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