Modelled DT Structure
Method:loop building
Template PDB:5LLU_A
Identity:73.905%
Minimized Score:-1189.818 kcal/mol
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0131 | ||||
| Gene Name | SLC1A3 | ||||
| Protein Name | Excitatory amino acid transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
|
||||
| Synonyms | EA6; EAAT1; GLAST; GLAST-1; GLAST1; SLC1A3; Sodium-dependent glutamate/aspartate transporter 1; Solute carrier family 1 member 3 | ||||
| DT Family | Dicarboxylate/Amino Acid:Cation (Na(+) Or H(+)) Symporter (DAACS) Family ; | ||||
| Tissue Specificity | Detected in brain (PubMed:8218410,PubMed:7521911, PubMed:8123008). Detected at very much lowerlevels in heart, lung, placenta and skeletal muscle(PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum,but also found in frontal cortex, hippocampus and basal ganglia(PubMed:7521911). | ||||
| Function | This sodium-dependent, high-affinity amino acid transporter functions as a symporter and mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. | ||||
| Endogenous Substrate(s) | Na+; Aspartate | ||||
| Variability Data of This Drug Transporter (DT) | |||||
|
Regulatory Variability Data of This DT (VARIDT 4.0) |
|||||
|
(α) Tissue Distribution Level of Excitatory amino acid transporter 1 |
|||||
|
(β) Cell Distribution Level of Excitatory amino acid transporter 1 |
|||||
|
(γ) Organelle Distribution Level of Excitatory amino acid transporter 1 |
|||||
|
Regulatory Variability Data of This DT |
|||||
|
(β) Post-translational Modification of Excitatory amino acid transporter 1 |
|||||
|
(γ) Transcriptional Regulation of Excitatory amino acid transporter 1 |
|||||
|
(δ) Epigenetic Regulation of Excitatory amino acid transporter 1 |
|||||
|
(ε) Exogenous Modulation of Excitatory amino acid transporter 1 |
|||||
|
Structural Variability Data of This DT |
|||||
|
(β) Inter-species Structural Differences |
|||||
|
(γ) Outward/inward-facing Conformation |
|||||
|
General Variability Data of This DT |
|||||
|
(α) Genetic Polymorphisms of Excitatory amino acid transporter 1 |
|||||
|
(β) Disease-specific Protein Abundances of Excitatory amino acid transporter 1 |
|||||
|
(γ) Species- and Tissue-specific DT Abundances |
|||||
| Molecular Transporting Profile of This DT | |||||
|
Full List of Drug(s) Transported by This DT |
|||||
|
Approved Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
|
L-glutamic acid
|
Approved | Drug Info | Schizophrenia | 6A20 | [1] |
|
Endogenous Metabolites (EMs) Handled by This DT |
|||||
|
Endogenous Metabolites (EMs) |
Click to Show/Hide the Full List of EMs: 1 EMs in Total | ||||
| EM Name | PubChem CID | Detail | Experimental Material | Ref | |
| Aspartate | EM Info | Identified using RPMI-8402 cell lines | [2] | ||
| References | |||||
| 1 | The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr-Jun;34(2-3):108-20. | ||||
| 2 | Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nat Cell Biol. 2018 Jul;20(7):775-781. | ||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.