Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0131 Transporter Info | ||||
| Gene Name | SLC1A3 | ||||
| Protein Name | Excitatory amino acid transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs1529461 | ||||
| Site of GPD | chr5:36689261 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>G | ||||
| Minor Allele Frequency | A=0.2590/512 (Global) | ||||
| Genotypes AA + AG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Antipsychotics | N.A. | Obsessive-compulsive Disorder | Genotypes AA + AG is associated with decreased response to antipsychotics in people with Schizophrenia as compared to genotype GG. | [ 1] | |
| References | |||||
| 1 | Synergistic association of PI4KA and GRM3 genetic polymorphisms with poor antipsychotic response in south Indian schizophrenia patients with low severity of illness. Am J Med Genet B Neuropsychiatr Genet. 2014 Dec;165B(8):635-46. | ||||
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